Language regression as a manifestation of epilepsy


  • Joana Ferreira Department of Pediatrics, Hospital Senhora da Oliveira - Guimarães
  • Sofia Lopes Department of Pediatrics, Hospital Senhora da Oliveira - Guimarães
  • José Carmona Lopes Department of Neurology, Hospital Senhora da Oliveira - Guimarães
  • Cristina Ferreira Department of Pediatrics, Hospital Senhora da Oliveira - Guimarães
  • Catarina Magalhães Department of Pediatrics, Hospital Senhora da Oliveira - Guimarães



cognition, epilepsy, epileptic syndromes, Landau-Kleffner syndrome


Introduction: Childhood epileptic encephalopathies are age-dependent brain disorders in which ictal and interictal epileptogenic activity is the apparent cause of progressive cognitive and neuro-psychological impairment.

Case report: A previously healthy four-year-old boy presented to the Emergency Department with a history of receptive and expressive language regression with four days of evolution, associated with seizure onset. Clinical features and electroencephalographic findings led to diagnosis of Landau-Kleffner syndrome. The boy was treated with valproate, clobazam, and prednisolone, with language improvement.

Discussion/Conclusion: Landau-Kleffner syndrome is a rare epileptic encephalopathy with pathognomonic sudden aphasia, epilepsy, and paroxysmal electroencephalographic abnormalities. The condition should be suspected in children with normal development who show a deterioration of established language skills. Early diagnosis and treatment are important to improve outcome.


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How to Cite

Ferreira J, Lopes S, Lopes JC, Ferreira C, Magalhães C. Language regression as a manifestation of epilepsy. REVNEC [Internet]. 2021Jun.30 [cited 2024Jul.17];30(2):99-104. Available from:



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