Biochemical clinical case


  • Joana Vanessa Silva Department of Pediatrics, Centro Hospitalar Entre Douro e Vouga
  • Joana Ferreira Department of Clinical Pathology, Centro Hospitalar Entre Douro e Vouga
  • Mariana Silva Department of Clinical Pathology, Centro Hospitalar Entre Douro e Vouga
  • Miguel Costa Department of Pediatrics, Centro Hospitalar Entre Douro e Vouga



blood protein disorder, electrophoresis, serum albumin


Bisalbuminemia is a qualitative albumin variation defined by coexistence of two types of serum albumin with different electrophoretic mobilities in the same individual. It can be of two different types: hereditary (or permanent) and acquired (or transient).

Herein is described a rare case of hereditary bisalbuminemia in a healthy infant, incidentally found during elevated aminotransferase study.

Despite not having pathological significance, acknowledgement of this analytical alteration is key for adequate management of these patients.


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Neild GH, Chakraborty S, Sural S, Sen S. Serum electrophoresis with a bifid albumin peak. Clin Kidney J. 2012;5(6):607.

Agarwal P, Parkash A, Tejwani N, Mehta A. Bisalbuminemia: A Rare Finding on Serum Electrophoresis. Indian J Hematol Blood Transfus. 2018;34(3):558-9.

Angouridaki C, Papageorgiou V, Tsavdaridou V, Giannousis M, Alexiou-Daniel S. Detection of hereditary bisalbuminemia in a Greek family by capillary zone electrophoresis. Hippokratia. 2008;12(2):119-21.

Bach-Ngohou K, Schmitt S, Le Carrer D, Masson D, Denis M. [Dysalbuminemia]. Ann Biol Clin (Paris). 2005;63(2):127-34.

Shetty JK, Maradi R, Prabhu K, Bhat G. Bisalbuminemia in a Hypothyroid Patient with Diabetes: A Case Report. J Clin Diagn Res. 2015;9(9):BD01-02.

Lefrere B, Dedome E, Garcia-Hejl C, Ragot C, Chianea D, Delacour H, et al. [Bisalbuminemia: A case report]. Rev Med Interne. 2018;39(12):950-4.

Sunthornthepvarakul T, Likitmaskul S, Ngowngarmratana S, et al. Familial dysalbuminemic hypertriiodothyroninemia: a new, dominantly inherited albumin defect. J Clin Endocrinol Metab. 1998;83(5):1448-54.

Petersen CE, Scottolini AG, Cody LR, Mandel M, Reimer N, Bhagavan NV. A point mutation in the human serum albumin gene results in familial dysalbuminaemic hyperthyroxinaemia. J Med Genet. 1994;31(5):355-9.

Faviou E, Nounopoulos C, Dionyssiou-Asteriou A. Bisalbuminemia from a clinical chemist’s viewpoint: a case report and review of the recent literature. Minerva Med. 2006;97(3):287-93.

Kragh-Hansen U, Minchiotti L, Galliano M, Peters T, Jr. Human serum albumin isoforms: genetic and molecular aspects and functional consequences. Biochim Biophys Acta. 2013;1830(12):5405-17.




How to Cite

Silva JV, Ferreira J, Silva M, Costa M. Biochemical clinical case. REVNEC [Internet]. 2021Dec.27 [cited 2024Jul.17];30(4):249-51. Available from:



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