Hemangioma infantil e propranolol oral – recomendações atuais
DOI:
https://doi.org/10.25753/BirthGrowthMJ.v25.i3.10078Palavras-chave:
hemangioma infantil, propranolol, lactente, criançaResumo
O hemangioma infantil é um tumor endotelial benigno ca- racterizado por um rápido crescimento nos primeiros meses de vida e regressão espontânea nos anos subsequentes. Desde 2008, o uso do propranolol oral tem sido crescente com eficácia superior à corticoterapia sistémica e ótimo perfil de segurança, assumindo uma posição de primeira linha no tratamento do he- mangioma infantil em idade pediátrica. Na presente revisão, os autores propõem uma atualização sobre as mais recentes reco- mendações para a abordagem dos doentes com hemangioma infantil e indicação para tratamento com propranolol oral.
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Kilcline C, Frieden IJ. Infantile hemangiomas: how common are they? A systemic review of the medical literature. Pediatr Dermatol. 2008; 25: 168.
Chiller KG, Passaro D, Frieden IJ. Hemangiomas of infancy: clinical characteristics, morphologic subtypes, and their relationship to race, ethnicity, and sex. Arch Dermatol. 2002; 138: 1567.
Barnes CM, Huang S, Kaipainen A. Evidence by molecular profiling for a placental origin of infantile hemangioma. Proc Natl Acad Sci USA. 2005; 102: 19097.
Bruckner AL, Frieden IJ. Hemangiomas of infancy. J Am Acad Dermatol. 2003; 48: 477.
Drolet BA, Esterly NB, Frieden IJ. Hemangiomas in children. N Engl J Med 1999; 341: 173.
Haggstrom AN, Drolet BA, Baselga E, Chamlin SL, Garzon MC, Horii KA, et al. Prospective study of infantile hemangioma: clinical characteristics predicting complications and treatment. Pediatrics. 2006; 118: 882-7.
Chang LC, Haggstrom AN, Drolet BA. Growth characteristics of infantile hemangiomas: implications for management. Paediatrics. 2008; 122: 360.
Chan YC, Giam YC. Guidelines of care for cutaneous hemangiomas. Ann Acad Med Singapore. 2005; 34: 117-23.
Bennett ML, Fleischer AB, Chamlin SL, Frieden IJ. Oral corticosteroid use is effective for cutaneous hemangiomas. Arch Dermatol 2001; 137: 1208-13.
Pandey A, Gangopadhyay AN, Sharma SP, Kumar V, Gupta DK, Gopal SC. Evaluation of topical steroids in the treatment of superficial hemangioma. Skinmed. 2010;8: 9-11.
Moehrle M, Léauté-Labrèze C, Schmidt V, Rocken M, Poets CF, Goelz R. Topical timolol for small hemangiomas of infancy. Pediatr Dermatol. 2013; 30: 245-9.
Bruscino N, Bonan P, Cannarozzo G, Moretti S, Lotti T, Campolmi P. Laser use in infantile hemangiomas, when and how. Dermatol Ther. 2012; 25: 314-21.
Melo IS, Gonçalves V, Anjos R. Propranolol nos hemangiomas infantis: casuística nacional com 30 doentes. Acta Pediatr Port. 2012; 43: 190-4.
Léauté-Labrèze C, de la Roque ED, Hubiche T, Boralevi F, Thambo JB, Thaieb A. Propranolol for severe hemangiomas of infancy. N Engl J MeF. 2008; 358: 2649-51.
Sanchez-Carpintero I, Ruiz-Rodriguez R, Lopez-Gutierrez. Propranolol in the Treatment of infantile hemangioma: clinical effectiveness, risks and recommendations. Actas Dermosifiliogr. 2011;102: 766-79.
Greenberg S, Bischoff J. Infantile haemangioma – mechanisms of drug action on a vascular tumor. Cold Spring Harb Perspect Med. 2011; 1: a006460.
Pereira J, Banquart-Leitão J. Propranolol como tratamento de primeira linha dos hemangiomas da infância. SPDV. 2014; 72: 101-8.
Drolet BA, Frommelt PC, Chamlin SL, Haggstrom A, Bauman NM, Chiu YE, et al. Initiation and use of propranolol for infantile hemangioma: report of a consensus conference. Pediatrics. 2013; 131: 128-40.
Raphael MF, Breugem CC, Vlasveld FAE, de Graaf M, Slieker MG, Pasmans SGMA, et al. Is cardiovascular evaluation necessary prior to and during beta-blocker therapy for infantile hemangiomas? A cohort study. J Am Acad Dermatol. 2014; 72: 465-72.
Lee KC, Bercovitch L. Update on infantile hemangiomas. Semin Perinatol. 2013; 37: 49-58.
Li YC, McCahon E, Rowe NA, Martin PA, Wilcsek GA, Martin FJ. Sucessful Treatment of infantile haemangiomas of the orbit with propranolol. Clin Experiment Ophthalmol. 2010;38: 554-9.
Manunza F, Syed S, Laguda B, Linward J, Kennedy H, Gholam K, et al. Propranolol for complicated infantile haemangiomas: a case series of 30 infants. Br J Dermatol. 2010;162: 466-8.
Caussé S, Aubert H, Saint-Jean M, Puzenat E, Bursztejn AC, Eschard C, et al. Propranolol-resistant infantile haemangiomas. Br J Dermatol. 2013; 169: 125-9.
Shehata N, Powell J, Dubois J, Hatami A, Rousseau E, Ondrejchak S, et al. Late rebound of infantile hemangioma after cessation of oral propranolol. Pediatr Dermatol. 2013. 30: 587-91.
NG SY, Kader Ibrahim SB. A case of PHACES syndrome with successful treatment of facial haemangioma with propranolol. Med J Malaysia. 2013; 4: 364-5.
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