O Papel dos Ácidos Gordos na Nutrição Humana e Desenvolvimentos Sobre o Modo Como Influenciam a Saúde

Authors

  • Raquel Guiné
  • F. Henriques

Abstract

Ao longo dos tempos tem-se verificado que os ácidos gordos fazem, cada vez mais, parte da alimentação, independentemente do continente, país e/ou cultura. Estes ácidos englobam vários constituintes e cada um deles tem a sua especificidade.
Os ácidos gordos mais importantes são os essenciais, caso do omega-3 e do omega-6, e desempenham um papel bastante significativo na saúde humana. Além disso, é necessário referir que desempenham funções de protecção, redução de risco e de inflamação em relação a determinadas doenças, tais como asma, cancro, hipertensão, lúpus, doenças de pele e oculares, depressão, entre outras.
Segundo alguns estudos realizados, a maior parte destes efeitos está comprovada, mas nem todos os casos estão ainda cientificamente aceites e existem casos em que, muitos dos autores entram em “conflito” devido a divergência de opiniões, por via de resultados eventualmente contraditórios obtidos em estudos quer “in vitro” quer “in vivo”. É, então, necessário verificar e comprovar todos estes potenciais efeitos, no sentido de verificar que os ácidos gordos, provavelmente, na sua maioria, podem funcionar muitas vezes como nutracêuticos ou complementar uma medicação em variadas situações.

Downloads

Download data is not yet available.

References

• Alexander, JW; Saito, H; Trocki, O; Ogle, CK. (1986). The Importance of Lipid Type in the Diet After Burn Injury. Ann Surg. 204(1), 1-8.

• al-Harbi, MM; Islam, MW; al-Shabanah, OA; al-Gharably, NM. (1995) Effect of Acute Administration of Fish Oil (Omega-3 Marine Triglyceride) on Gastric Ulceration and Secretion Induced by Various Ulcerogenic and Necrotizing Agents in Rats. Food Chem. Toxicol., 33(7), 553-558.

• Aragona, P; Bucolo, C; Spinella, R; Giuffrida, S; Ferreri, G. (2005). Systemic Omega-6 Essential Fatty Acid Treatment and PGE1 Tear Content in Sjögren’s Syndrome Patients. Investigative Ophthalmology and Visual Science, 46, 4474-4479.

• Ariza-Ariza, R; Mestanza-Peralta, M; Cardiel, MH. (1998). Omega-3 Fatty Acids in Rheumatoid Arthritis: an Overview. Semin. Arthrit Rheum., 27(6), 366-370.

• Bagga, D; Wang, L; Farias-Eisner, R; Glaspy, JA; Reddy, ST. (2003). Differential Effects of Prostaglandin Derived From ω-6 and ω-3 Polyunsaturated Fatty Acids on COX-2 Expression and IL-6 Secretion. Proc. Natl. Acad. Sci. USA., 100(4), 1751-1756.

• Baguma-Nibasheka, M; Brenna, JT; Nathanielsz, PW. (1999). Delay of Preterm Delivery in Sheep by Omega-3 Long-chain Polyunsaturates. Biol. Reprod., 60(3), 698-701.

• Barabino, S; Rolando, M; Camicione, P; Ravera, G; Zanardi, S; Giuffrida, S; Calabria, G. (2003). Systemic Linoleic and [gamma]-Linolenic Acid Therapy in Dry Eye Syndrome With an Inflammatory Component. Cornea, 22(2), 97-101.

• Bartsch, H; Nair, J; Owen, RW. (1999). Dietary Polyunsaturated Fatty Acids and Cancers of the Breast and Colorectum: Emerging Evidence for their Role as Risk Modifiers. Carcinogenesis, 20(12), 2209-2218.

• Belch, JJ; Ansell, D; Madhok, R; O'Dowd, A; Sturrock, RD. (1988). Effects of Altering Dietary Essential Fatty Acids on Requirements for Non-steroidal Anti-inflammatory Drugs in Patients with Rheumatoid Arthritis: a Double Blind Placebo Controlled Study. Ann. Rheum. Dis., 47(2), 96-104.

• Belluzzi, A; Boschi, S; Brignola, C; Munarini, A; Cariani, G; Miglio, F. (2000). Polyunsaturated Fatty Acids and Inflammatory Bowel Disease. American Journal of Clinical Nutrition, 71(1), 339S-342S.

• Bidoli, E; Talamini, R; Bosetti, C; Negri, E; Maruzzi, D; Montella, M; Franceschi, S; La Vecchia, C. (2005). Macronutrients, Fatty Acids, Cholesterol and Prostate Cancer Risk. Annals of Oncology, 16(1), 152-157.

• Brookes, KJ; Chen, W; Xu, X; Taylor, E; Asherson, P. (2006). Association of Fatty Acid Desaturase Genes with Attention-deficit/hyperactivity Disorder. Biol. Psychiatry., 60(10), 1053-1061.

• Brown, JM; McIntosh, MK. (2005). Conjugated Linoleic Acid in Humans: Regulation of Adiposity and Insulin Sensitivity. J. Nutr., 133, 3041-3046.

• Calabresi, L; Villa, N; Canavesi, M; Sirtori, CR; James, RW; Bernini, F; Franceschini, G. (2004). An Omega-3 Polyunsaturated Fatty Acid Concentrate Increases Plasma High-density Lipoprotein 2 Cholesterol and Paraoxonase Levels in Patients with Familial Combined Hyperlipidemia. Metabolism, 53(2),153-158.

• Calder, PC; Zurier, RB. (2001.). Polyunsaturated Fatty Acids and Rheumatoid Arthritis. Curr. Opin. Clin. Nutr. Metab. Care., 4(2), 115-121.

• Cangemi, FE. (2007). TOZAL Study: An Open Case Control Study of an Oral Antioxidant and Omega-3 Supplement for Dry AMD. BMC Ophthalmol., 7: 3.

• Chapkin, RS; McMurray, DN; Lupton, JR. (2007). Colon Cancer, Fatty Acids and Anti-Inflammatory Compounds. Curr. Opin. Gastroenterol., 23(1), 48-54.

• Cho, E; Hung, S; Willett, WC; Spiegelman, D; Rimm, EB; Seddon, JM; Colditz, GA; Hankinson, SE. (2001). Prospective Study of Dietary Fat and the Risk of Age-related Macular Degeneration. American Journal of Clinical Nutrition, 73 (2) 209-218.

• Clark, WF; Parbtani, A. (1994). Omega-3 Fatty Acid Supplementation in Clinical and Experimental Lupus Nephritis. Am. J. Kidney Dis., 23(5), 644-647.

• Das, UN. (2000). Essential Fatty Acids and Osteoporosis. Nutrition, 16(5), 386-390.

• Deutch, B. (1995). Menstrual Pain in Danish Women Correlated with Low n-3 Polyunsaturated Fatty Acid Intake. Eur. J. Clin. Nutr., 49(7), 508-516.

• Emsley, R; Oosthuizen, P; van Rensburg, SJ. (2003). Clinical potential of omega-3 fatty acids in the treatment of schizophrenia. CNS Drugs., 17(15), 1081-1091.

• Feher, J; Kovasc, B; Kovacs, I; Schvoller, M; Papale, A; Gabrieli, CB. (2005)- Improvement of Visual Functions and Fundus Alterations in Early Age-related Macular Degeneration Treated with a Combination of Acetyl-L-carnitine, n-3 Fatty Acids, and Coenzyme Q10. Ophthalmologica, 219(3), 154-166.

• Fleischhauer, FJ; Yan, WD; Fischell, TA. (1993). Fish Oil Improves Endothelium-dependent Coronary Vasodilation in Heart Transplant Recipients. J. Am. Coll. Cardiol., 21(4), 982-989.

• Gassull, MA. (2004). The Role of Nutrition in The Treatment of Inflammatory Bowel Disease Alimentary Pharmacology & Therapeutics, 20(s4), 79-83.

• Geleijnse, JM; Giltay, EJ; Grobbee, DE; Donders, AR; Kok, FJ. (2002). Blood Pressure Response to Fish Oil Supplementation: Metaregression Analysis of Randomized Trials. J. Hypertens., 20(8), 1493-1499.

• Griel, AE; Kris-Etherton, PM; Hilpert, KF; Zhao, G; West, SG; Corwin, RL. (2007). An Increase in Dietary n-3 Fatty Acids Decreases a Marker of Bone Resorption in Humans. Nutr. J., 6: 2.

• Hall, MN; Campos, H; Li, H; Sesso, HD; Stampfer, MJ; Willett, WC; Ma, J. (2007). Blood Levels of Long-Chain Polyunsaturated Fatty Acids, Aspirin, and the Risk of Colorectal Cancer. Cancer Epidemiology Biomarkers & Prevention, 16(2), 314-321.

• Harris, WS. (2004). Are Omega-3 Fatty Acids the Most Important Nutritional Modulators of Coronary Heart Disease Risk? Curr. Atheroscler. Rep., 6(6), 447-452.

• Harris, WS. (1989). Fish Oils and Plasma Lipid and Lipoprotein Metabolism in Humans: a Critical Review. J. Lipid. Res., 30(6), 785–807.

• Herrmann, W; Biermann, J; Kostner, GM. (1995). Comparison of Effects of N-3 to N-6 Fatty Acids on Serum Level of Lipoprotein(a) in Patients with Coronary Artery Disease. Am. J. Cardiol., 76(7), 459-462.

• Hibbeln, JR; Salem Jr, N. (1995). Dietary Polyunsaturated Fatty Acids and Depression: When Cholesterol Does Not Satisfy. American Journal of Clinical Nutrition, 62, 1-9,

• Hirsch, J. (2002). The Search for New Ways to Treat Obesity. Proc. Natl. Acad. Sci. U S A., 99(14), 9096-9097.

• Hodge, WG; Schachter, HM; Barnes, D; Pan, Y; Lowcock, EC; Zhang, L; Sampson, M; Morrison, A; Tran, K; Miguelez, M; Lewin, G. (2006). Efficacy of Omega-3 Fatty Acids in Preventing Age-related Macular Degeneration: a Systematic Review. Ophthalmology, 113(7), 1165-1172.

• Holman, RT; Adams, CE; Nelson, RA; Grater, SJE; Jaskiewicz, JA; Johnson, SB; Erdman Jr., JW. (1995)- Patients with Anorexia Nervosa Demonstrate Deficiencies of Selected Essential Fatty Acids, Compensatory Changes in Nonessential Fatty Acids and Decreased Fluidity of Plasma Lipids. J. Nutr., 125, 901-907.

• Holub, BJ. (2002). Clinical Nutrition: 4. Omega-3 Fatty Acids in Cardiovascular Care. CMAJ, 166(5), 608-615.

• Jones, PJ. (2002). Clinical Nutrition: 7. Functional foods — More Than Just Nutrition. CMAJ, 166(12), 1555-1563.

• Joshi, K; Lad, S; Kale, M; Patwardhan, B; Mahadik, SP; Patni, B; Chaudhary, A; Bhave, S; Pandit, A. (2006). Supplementation with Flax Oil and Vitamin C Improves the Outcome of Attention Deficit Hyperactivity Disorder (ADHD). Prostaglandins Leukot Essent Fatty Acids, 74(1), 17-21.

• Kelavkar, UP; Hutzley, J; Dhir, R; Kim, P; Allen, KGD; McHugh, K. (2006). Prostate Tumor Growth and Recurrence Can Be Modulated by the ω-6:ω-3 Ratio in Diet: Athymic Mouse Xenograft Model Simulating Radical Prostatectomy. Neoplasia, 8(2), 112–124.

• Kremer, JM. (2000). N-3 Fatty Acid Supplements in Rheumatoid Arthritis. American Journal of Clinical Nutrition, 71(1), 349S-351S.

• Kuriki, K; Wakai, K; Hirose, K; Matsuo, K; Ito, H; Suzuki, T; Saito, T; Kanemitsu, Y; Hirai, T; Kato, T; Tatematsu, M; Tajima, K. (2006). Risk of Colorectal Cancer Is Linked to Erythrocyte Compositions of Fatty Acids as Biomarkers for Dietary Intakes of Fish, Fat, and Fatty Acids. Cancer Epidemiology Biomarkers & Prevention, 15(10), 1791-1798.

• Laugharne, JD; Mellor, JE; Peet, M. (1996). Fatty Acids and Schizophrenia. Lipids, 31(Suppl.), S163-S165.

• Logan, AC. (2004). Omega-3 Fatty Acids and Major Depression: A Primer for the Mental Health Professional. Lipids Health Dis., 3: 25.

• Maillard, V; Bougnoux, P; Ferrari, P; Jourdan, ML; Pinault, M; Lavillonniere, F; Body, G; Le Floch, O; Chajes, V. (2002). N-3 and N-6 Fatty Acids in Breast Adipose Tissue and Relative Risk of Breast Cancer in a Case-control Study in Tours, France. Int. J. Cancer, 98(1), 78-83.

• Martirosyan, DM; Miroshnichenko, LA; Kulakova, SN; Pogojeva, AV; Zoloedov, VI. (2007). Amaranth Oil Application for Coronary Heart Disease and Hypertension. Lipids Health Dis., 6: 1.

• Massaro, M, Habib, A; Lubrano, L; Turco, SD; Lazzerini, G; Bourcier, T; Weksler, BB; De Caterina, R. (2006). The Omega-3 Fatty Acid Docosahexaenoate Attenuates Endothelial Cyclooxygenase-2 Induction Through Both NADP(H) Oxidase and PKCε Inhibition. Proc. Natl. Acad. Sci. USA., 103(41), 15184-15189.

• Mayser, P; Grimm, H; Grimminger, F. (2002). n-3 Fatty Acids in Psoriasis. Br. J. Nutr., 87(Suppl.1), S77-S82.

• Mayser, P; Mrowietz, U; Arenberger, P; Bartak, P; Buchvald, J; Christophers, E; Jablonska, S; Salmhofer, W; Schill, WB; Kramer, HJ; Schlotzer, E; Mayer, K; Seeger, W; Grimminger, F. (1998). Omega-3 Fatty Acid-based Lipid Infusion in Patients With Chronic Plaque Psoriasis: Results of a Double-blind, Randomized, Placebo-controlled, Multicenter Trial. J. Am. Acad. Dermatol., 38(4), 539-547.

• Mickleborough, TD; Ionescu, AA; Rundell, KW. (2004). Omega-3 Fatty Acids and Airway Hyperresponsiveness in Asthma. The Journal of Alternative and Complementary Medicine, 10(6), 1067-1075.

• Mori, TA; Beilin, LJ; Burke, V; Morris, J; Ritchie, J. (1997). Interactions Between Dietary Fat, Fish, and Fish Oils and their Effects on Platelet Function in Men at Risk of Cardiovascular Disease. Arterioscler. Thromb. Vasc. Biol., 17(2), 279-286.

• Mozaffarian, D; Ascherio, A; Hu, FB; Stampfer, MJ; Willett, WC; Siscovick, DS; Rimm, EB. (2005)- Interplay Between Different Polyunsaturated Fatty Acids and Risk of Coronary Heart Disease in Men. Circulation., 111(2), 157-164.

• Mukherjee, PK; Marcheselli, VL; Serhan, CN; Bazan, NG. (2004). Neuroprotectin D1: A Docosahexaenoic Acid-derived Docosatriene Protects Human Retinal Pigment Epithelial Cells from Oxidative Stress. Proc. Natl. Acad. Sci. USA, 101(22), 8491–8496.

• Muller-Esterl, W; Kruger, MC; Horrobin, DF. (1997. Calcium Metabolism, Osteoporosis and Essential Fatty Acids: a Review. Progress in Lipid Research, 36(2), 131-151.

• Nagakura, T; Matsuda, S; Shichijyo, K; Sugimoto, H; Hata, K. (2000). Dietary Supplementation With Fish Oil Rich in Omega-3 Polyunsaturated Fatty Acids in Children With Bronchial Asthma. Eur. Respir. J., 16, 861-865.

• Navarro, E; Esteve, M; Olive, A; Klaassen, J; Cabre, E; Tena X; Fernandez-Banares, F; Pastor, C; Gassull, MA. (2000). Abnormal Fatty Acid Pattern in Rheumatoid Arthritis. A Rationale for Treatment with Marine and Botanical Lipids. Journal of Rheumatology, 27(2), 298-303.

• Newman, MJ. (1990). Inhibition of Carcinoma and Melanoma Cell Growth by Type 1 Transforming Growth Factor Beta is Dependent on the Presence of Polyunsaturated Fatty Acids. Proc. Natl. Acad. Sci. USA, 87(14), 5543–5547

• Oddy, W; de Klerk, N; Kendall, G; Mihrshahi, S; Peat, J. (2005). Ratio of Omega-6 to Omega-3 Fatty Acids and Childhood Asthma. Journal of Asthma, 41(3), 319-326.

• Ouchia, M; Ikedab, T; Nakamurac, K; Harinod, S; Kinoshitaa, S. (2002). A Novel Relation of Fatty Acid with Age-Related Macular Degeneration. Ophthalmologica, 216(5), 363-367.

• Pratt, VC; Tredget, EE; Clandinin, MT; Field, CJ. (2001). Fatty Acid Content of Plasma Lipids and Erythrocyte Phospholipids are Altered Following Burn Injury. Lipids, 36(7), 675-682.

• Reisman, J; Schachter, HM; Dales, RE; Tran, K; Kourad, K; Barnes, D; Sampson, M; Morrison, A; Gaboury, I; Blackman, J. (2006). Treating Asthma With Omega-3 Fatty Acids: Where is the Evidence? A Systematic Review. BMC Complementary and Alternative Medicine, 19(6): 26.

• Rosenberg, IH. (2002). Fish-food to Calm the Heart. N .Engl. J. Med. 346(15), 1102-1103.

• Sagduyu, K; Dokucu, ME; Eddy, BA; Craigen, G; Baldassano, CF; Yıldız, A. (2005). Omega-3 Fatty Acids Decreased Irritability of Patients with Bipolar Disorder in an Add-on, Open Label Study. Nutr. J., 4: 6.

• Sanders, TA; Haines, AP; Wormald, R; Wright, LA; Obeid, O. (1993). Essential Fatty Acids, Plasma Cholesterol, and Fat-soluble Vitamins in Subjects with Age-related Maculopathy and Matched Control Subjects. American Journal of Clinical Nutrition, 57(3), 428-433.

• Schwalfenberg, G. (2006). Omega-3 Fatty Acids: Their Beneficial Role in Cardiovascular Health. Can. Fam. Physician., 52(6), 734-740.

• Schwartz, J. (2000) Role of Polyunsaturated Fatty Acids in Lung Disease. American Journal of Clinical Nutrition, 71(1)(Supp.), 393S-396S.

• Seddon, JM; Rosner, B; Sperduto, RD; Yannuzzi, L; Haller, JA; Blair, NP; Willett, W. (2001). Dietary Fat and Risk for Advanced Age-related Macular Degeneration. Arch. Ophthalmol., 119(8), 1191-1199.

• Shannon, J; King, IB; Moshofsky, R; Lampe, JW; Gao, DL; Ray, RM; Thomas, DB. (2007)- Erythrocyte Fatty Acids and Breast Cancer Risk: a Case-control Study in Shanghai, China. American Journal of Clinical Nutrition, 85(4), 1090-1097.

• Simonsen, N; van't Veer, P; Strain, JJ; Martin-Moreno, JM; Huttunen, JK; Navajas, JF-C; Martin, BC; Thamm, M; Kardinaal, AFM; Kok, FJ; Kohlmeier, L. (1998). Adipose Tissue Omega-3 and Omega-6 Fatty Acid Content and Breast Cancer in the EURAMIC Study. American Journal of Epidemiology, 147(4), 342-352.

• Simpson, HC; Barker, K; Carter, RD; Cassels, E; Mann, JI. (1982). Low Dietary Intake of Linoleic Acid Predisposes to Myocardial Infarction. Br. Med. J. (Clin. Res. Ed)., 285(6343), 683-684.

• Sinn, N; Bryan, J. (2007). Effect of Supplementation with Polyunsaturated Fatty Acids and Micronutrients on Learning and Behavior Problems Associated with Child ADHD. J. Dev. Behav. Pediatr., 28(2), 82-91.

• Smith, WL. (1989). The Eicosanoids and Their Biochemical Mechanisms of Action. Biochem. J. 259(2), 315-324.

• Stoll, AL; Locke, CA; Marangell, LB; Severus, WE. (1999a). Omega-3 Fatty Acids and Bipolar Disorder: a Review. Prostaglandins Leukot Essent Fatty Acids, 60(5-6), 329-337.

• Stoll, AL; Severus, WE; Freeman, MP; Rueter, S; Zboyan, HA; Diamond, E; Cress, KK; Marangell, LB. (1999b). Omega 3 Fatty Acids in Bipolar Disorder: a Preliminary Double-blind, Placebo-controlled Trial. Arch. Gen. Psychiatry., 56(5), 407-412.

• Thies, F; Garry, JM; Yaqoob, P; Rerkasem, K; Williams, J; Shearman, CP; Gallagher, PJ; Calder, PC; Grimble, RF. (2003). Association of n-3 Polyunsaturated Fatty Acids With Stability of Atherosclerotic Plaques: a Randomised Controlled Trial. Lancet., 361(9356), 477-485.

• Tiemeier, H; van Tuijl, HR; Hofman, A; Kiliaan, AJ; Breteler, MM. (2003). Plasma Fatty Acid Composition and Depression are Associated in the Elderly: the Rotterdam Study. Am. J. Clin. Nutr., 78(1), 40-46.

• Vanek, C; Connor, WE. (2007). Do n–3 Fatty Acids Prevent Osteoporosis? American Journal of Clinical Nutrition, 85(3), 647-648.

• Walton, AJ; Snaith, ML; Locniskar, M; Cumberland, AG; Morrow, WJ; Isenberg, DA. (1991). Dietary Fish Oil and the Severity of Symptoms in Patients with Systemic Lupus Erythematosus. Ann. Rheum. Dis., 50(7), 463-466.

• Watanabe, S; Sakurada, M; Suji, HT; Matsumoto, S; Kondo, K. (2005). Efficacy of γ-linolenic Acid for Treatment of Premenstrual Syndrome, as Assessed by a Prospective Daily Rating System. Journal of Oleo Science, 54(4), 217-224.

• Woods, RK; Raven, JM; Walters, EH; Abramson, MJ; Thien, FCK. (2004). Fatty Acid Levels and Risk of Asthma in Young Adults. Thorax, 59(2), 105-110.

• Xia, S; Lu, Y; Wang, J; He, C; Hong, S; Serhan, CN; Kang, JX. (2006). Melanoma Growth is Reduced in Fat-1 Transgenic Mice: Impact of Omega-6/Omega-3 Essential Fatty Acids. Proc. Natl. Acad. Sci. USA, 103(33), 12499–12504.

• Yuan, G; Al-Shali, KZ; Hegele, RA. (2007). Hypertriglyceridemia: Its Etiology, Effects and Treatment. CMAJ., 176(8), 1113-1120.

• Zhao, G; Etherton, TD; Martin, KR; West, SG; Gillies, PJ; Kris-Etherton, PM. (2004). Dietary Alpha-linolenic Acid Reduces Inflammatory and Lipid Cardiovascular Risk Factors in Hypercholesterolemic Men and Women. J. Nutr., 134(11), 2991-2997.

• Zurier, B. (1991). Essential Fatty Acids and Inflammation. Ann. Rheum. Dis., 50(11), 745-746.

Published

2016-02-03

How to Cite

Guiné, R., & Henriques, F. (2016). O Papel dos Ácidos Gordos na Nutrição Humana e Desenvolvimentos Sobre o Modo Como Influenciam a Saúde. Millenium - Journal of Education, Technologies, and Health, (40), 7–21. Retrieved from https://revistas.rcaap.pt/millenium/article/view/8216

Issue

Section

Articles