Tympanic paragangliomas
case reports
DOI:
https://doi.org/10.29352/mill0206e.05.00349Keywords:
glomus tympanicum, paraganglioma, neoplasms, tinnitusAbstract
Introduction: Tympanic glomus tumors, or paragangliomas, are vascular tumors located on the middle ear promontory, formed by cells with finely granulated eosinophilic cytoplasm with small oval nucleus separated by septa of fibrous tissue containing dilated veins.
Development: These tympanic tumors are very similar histologically to pheochromocytoma and are considered the most common benign tumors of the middle ear. The most reported symptoms are pulsatile tinnitus and hearing loss. Physical examination may show a reddish lesion in the middle ear. The diagnosis by complementary exams is made with the tomography of the temporal bones and nuclear magnetic resonance, when necessary, and audiometry.
Conclusions: This article presents two cases of patients with tympanic paragangliomas treated surgically, with different clinical conditions despite having similar lesions, showing resolutive conduct for an unusual picture.
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Appannan, V. R., & Md Daud, M. K. (2018). Glomus tympanicum. Malaysian Family Physician: The Official Journal of the Academy of Family Physicians of Malaysia, 13(1), 45-48. Retrieved from https://europepmc.org/article/med/29796211
Baysal, B. E., van Schothorst, E. M., Farr, J. E., Grashof, P., Myssiorek, D., Rubinstein, W. S.,… Richard III, C. W. (1999). Repositioning the hereditary paraganglioma critical region on chromosome band 11q23. Human Genetics, 104(3), 219-225. doi: 10.1007/s004390050939
Bogar, P., Freitas, E. B., Caropreso, C. A., Miniti, A., Silva, J. C. R., & Bento, R. F. (1990). Glomus timpânico: Diagnóstico e tratamento. Apresentação de três casos. Brazilian Journal of Otorhinolaryngology, 56(1), 33-36. Retrieved from http://oldfiles.bjorl.org/conteudo/acervo/acervo.asp?id=2290
Chen, H., Sippel, R. S., O'Dorisio, M. S., Vinik, A. I., Lloyd, R. V., Pacak, K., & North American Neuroendocrine Tumor Society. (2010). The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: Pheochromocytoma, paraganglioma, and medullary thyroid cancer. Pancreas, 39(6), 775-783. doi: 10.1097/MPA.0b013e3181ebb4f0.
Erickson, D., Kudva, Y. C., Ebersold, M. J., Thompson, G. B., Grant, C. S., van Heerden, J. A., & Young, W. F., Jr (2001). Benign paragangliomas: Clinical presentation and treatment outcomes in 236 patients. The Journal of Clinical Endocrinology and Metabolism, 86(11), 5210-5216. https://doi.org/10.1210/jcem.86.11.8034.
Fisch, U., & Mattox, D. E. (1988). Microsurgery of the skull base. Stuttgart, New York: Thieme.
Fleury, P., Legent, F., Marsault, C., Basset, J. M., Sterkers, O., & Compere, J. F. (1979). Voies endaurales et chirurgie des tumeurs du glomus jugulaire (G.J.). Annales d'Oto-laryngologie et de Chirurgie Cervico Faciale : Bulletin de la Societe d'Oto-laryngologie des Hopitaux de Paris, 96(10-11), 699-731.
Neto, M. E. L. R. V., Vuono, I. M., Souza, L. R. O., Testa, J. R. G., Pizarro, G. U., & Barros, F. (2005). Paragangliomas timpânicos: Relato de casos. Revista Brasileira de Otorrinolaringologia, 71(1), 97-100. https://doi.org/10.1590/S0034-72992005000100018
Neumann, H. P. H., Young, W. F., & Eng, C. (2019). Pheochromocytoma and paraganglioma. New England Journal of Medicine, 381(6), 552-565. doi: 10.1056/NEJMra1806651.
O'Leary, M. J., Shelton, C., Giddings, N. A., Kwartler, J., & Brackmann, D. E. (1991). Glomus tympanicum tumors: A clinical perspective. The Laryngoscope, 101(10), 1038-1043. https://doi.org/10.1288/00005537-199110000-00002
Singh, V. K., Badhwar, S., D'Souza, J., & Indrajit, I. K. (2004). Glomus Tympanicum. Medical journal, Armed Forces India, 60(2), 200-203. https://doi.org/10.1016/S0377-1237(04)80125-4
Schipper, J., Boedeker, C. C., Maier, W., & Neumann, H. P. H. (2004). Paragangliome im kopf-/halsbereich. Teil 1: Systematik und diagnostik. HNO, 52(6), 569-575.
Spector, G. J., Maisel, R. H., & Ogura, J. H. (1973). Glomus tumors in the middle ear. I: An analysis of 46 patients. The Laryngoscope, 83(10), 1652-1672. https://doi.org/10.1288/00005537-197310000-00007
Sweeney, A. D., Carlson, M. L., Wanna, G. B., & Bennett, M. L. (2015). Glomus tympanicum tumors. Otolaryngologic Clinics of North America, 48(2), 293-304. https://doi.org/10.1016/j.otc.2014.12.004
Thompson, L. D. R. (2006). World health organization classification of tumours: Pathology and genetics of head and neck tumours. Ear, Nose and Throat Journal, 85(2), 74. https://doi.org/10.1177/014556130608500201
Tiago, R. S. L., Gil, F. M., Ribeiro, J. T., Anjos, P. S. F., Sens, P. M., & Valle, L. O. (2007). Paraganglioma timpânico: A propósito de dois casos. Revista Brasileira de Otorrinolaringologia, 73(1), 143. https://doi.org/10.1590/S0034-72992007000100027
Welander, J., Söderkvist, P., & Gimm, O. (2011). Genetics and clinical characteristics of hereditary pheochromocytomas and paragangliomas. Endocrine-Related Cancer, 18(6), R253-R276. https://doi.org/10.1530/ERC-11-0170
Woods, C. I., Strasnick, B., & Jackson, C. G. (1993). Surgery for glomus tumors: The Otology Group experience. The Laryngoscope, 103(11 Pt 2 Suppl 60), 65–70. doi: 10.1002/lary.1993.103.s60.65.
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