Perception of the impact of NeuronUP in the cognitive rehabilitation of people with acquired brain injury and Huntington´ s disease

Authors

DOI:

https://doi.org/10.29352/mill0230.47011

Keywords:

brain injuries; Huntington disease; cognitive impairment; cognitive rehabilitation; therapy, computer-assisted

Abstract

Introduction: Cognitive rehabilitation has gained relevance in the treatment, improvement, and maintenance of cognitive functioning in individuals affected by neurological disorders. ICTs have transformed cognitive treatments by effectively integrating into therapeutic approaches. In this context, NeuronUP is presented as a computer software designed for cognitive rehabilitation.

Objective: 1) to examine the effectiveness of the NeuronUP platform in individuals diagnosed with Huntington’s Disease and Acquired Brain Injury; and 2) to explore and analyze users’ perceived experiences and their satisfaction with the application.

Methods: A mixed-methods study is presented. A total of 12 subjects participated: 6 with Huntington's Disease and 6 with Acquired Brain Injury. The cognitive scores used in the study were obtained through the Mini-Mental State Examination (Lobo et al., 1979), and the experience was gained through the interviews.

Results: The results show a significant cognitive improvement in patients with Acquired Brain Injury and stability in patients with Huntington's Disease, together with a positive evaluation of the rehabilitation by the users, who highlight benefits in memory, attention and autonomy.

Conclusion: These findings support the effectiveness of digital tools such as NeuronUP in cognitive rehabilitation as a complement to conventional therapies.

Downloads

Download data is not yet available.

References

Alashram, A.R. (2026). Computerized cognitive rehabilitation for patients with traumatic brain injury: A systematic review of randomized controlled trials. Applied Neuropsychology: Adult, 33(2), 578-587. https://doi.org/10.1080/23279095.2024.2350607

Arango Lasprilla, J. C., & Olabarrieta Landa, L. (2019). Daño cerebral. El Manual Moderno.

Calderón-Chagualá, J. A., Montilla-García, M. Á., Gómez, M., Ospina-Viña, J. E., Triana-Martínez, J. C., y Vargas-Martínez, L. C. (2019). Rehabilitación neuropsicológica en daño cerebral: uso de herramientas tradicionales y realidad virtual. Revista Mexicana de Neurociencia, 20(1) 29-35. https://doi.org/10.24875/rmn.m22000089

Creswell, J. W., & Plano Clark, V. L. (2017). Designing and conducting mixed methods research (3ª ed.). SAGE.

Cuaspud Naranjo, Á. G., & Ardila Villareal, G. M. (2024). Neuroplasticidad cerebral en pacientes con daño cerebral adquirido. CEI Boletín Informativo, 11(3), 48-50. https://shre.ink/jYKP

Cusme Yagual, J. A., & Pucuna Guapi, E. E. (2024). Enfermedad de Huntington. En D. S. Ponce Miranda, G. A., Paz Sánchez, M., Quimbayo Polo, J. P., Acosta Dlyuz, H. A., Parrales Briones, E. F., Hualpa Galarza, B. S., Pazmiño Antepara, J. J., Tituana Moreira, J. A., Cusme Yagual, E. E., Pucuna Guapi, G. C., Villamar Flores, D., Flores Lucas, S., & Matute Solís, D. M. Actualización en Neurología Vol. 1, 116-132. Cuevas Editores SAS. https://doi.org/10.56470/978-9942-660-18-3

Daiver, A., Doria Mass, C. L., Doria Pedraza, C., & Salas Álvarez, D. J. (2021). Implementación de una aplicación móvil como herramienta de prevención del Alzheimer y el deterioro cognitivo en adultos mayores. Revista Infométrica, 4(1), 1-10. https://www.infometrica.org/index.php/syh/article/view/169

European Parliament and the Council. (2016). EU General Data Protection Regulation 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC. Official Journal of the European Union, L 119, 2016, May 4 (pp. 1-88). http://data.europa.eu/eli/reg/2016/679/oj

Fabara-Rodríguez, A. C., García-Bravo, C., García-Bravo, S., Quirosa-Galán, I., Rodríguez-Pérez, M. P., Pérez-Corrales, J., Fernández-Gómez, G., Donovan, M., & Huertas-Hoyas, E. (2024). Quality-of-Life- and Cognitive-Oriented Rehabilitation Program through NeuronUP in Older People with Alzheimer's Disease: A Randomized Clinical Trial. Journal of Clinical Medicine, 13(19), 5982. https://doi.org/10.3390/jcm13195982

Fernández-Sánchez, M., Aza-Hernández, A., & Verdugo-Alonso, M. Á. (2022). Modelos de atención pública a la población con daño cerebral adquirido en España: Un estudio de la situación por comunidades autónomas. Revista de Neurología, 74(8), 245-257. https://doi.org/10.33588/rn.7408.2021372

Fritz N. E., Rao A. K., Kegelmeyer, D. A., Kloos, A., Bussed, M., Harlel, L., Carrier, J., & Quinn, L. (2017). Physical therapy and exercise interventions in Huntington's disease: a mixed methods systematic review. Journal of Huntington's Disease, 6(3), 217-236. https://doi.org/10.3233/JHD-170260

Gómez Pulido, M. A. (2023). Rehabilitación neuropsicológica holística: Evolución cognitiva y calidad de vida de pacientes con daño cerebral adquirido. Siglo Cero, 54(2), 93-114. https://doi.org/10.14201/scero202354227894

Guadamuz Delgado, J., Miranda Saavedra, M., & Mora Miranda, N. (2022). Actualización sobre neuroplasticidad cerebral. Revista Médica Sinergia, 7(6). https://doi.org/10.31434/rms.v7i6.829

Guest, G., & Fleming, P. (2015). Mixed Methods Research. In G. Guest, G. & E. Namey (Eds.), Public Health Research Methods (pp. 581-614). SAGE. https://doi.org/10.4135/9781483398839

Huynh, K., Jamadar, S. D., Lampit, A., Siddiqui, M. N., Stout, J. C., & Georgiou-Karistianis, N. (2025). Feasibility and effects of cognitive training on cognition and psychosocial function in Huntington's disease: a randomised pilot trial. Journal of Neurology, 272(2), 159. https://doi.org/10.1007/s00415-024-12855-7

Irazoki, E., Sánchez-Gómez, M. C., Contreras-Somoza, L. M., Toribio-Guzmán, J. M., Martín-Cilleros, M. V., Verdugo-Castro, S., Jenaro-Río, C., & Franco-Martín, M. A. (2021). A Qualitative Study of the Cognitive Rehabilitation Program GRADIOR for People with Cognitive Impairment: Outcomes of the Focus Group Methodology. Journal of Clinical Medicine, 10(4), 859. https://doi.org/10.3390/jcm10040859

Kim, H. S., Choi, Y. H., Lee, K. M., Kim, B. R., Han, E. Y., & Kim, S. H. (2021). The efficacy of computerized cognitive rehabilitation in improving attention and executive functions in acquired brain injury patients, in acute and postacute phase. European Journal of Physical and Rehabilitation Medicine, 57(1), 19-27. https://doi.org/10.23736/S1973-9087.20.06275-0

Lobo, A., Ezquerra, J., Gómez Burgada, F., Sala, J. M., & Seva Díaz, A. (1979). El Mini-Examen Cognoscitivo: Un test sencillo y práctico, para detectar alteraciones intelectuales en pacientes médicos. Actas Luso-Españolas de Neurología, Psiquiatría y Ciencias Afines, 7(3), 189-202. https://shre.ink/jYK0

Lobo, A., Saz, P., & Marcos, G. (2002). Manual MMSE. Examen cognoscitivo Mini-Mental. TEA.

Lopes, A. J. O., Martins, V., & Ribeiro, J. (2017). Dementia Approach and Follow-up in Primary Care. Millenium - Journal of Education, Technologies, and Health, 2(3), 37–44. https://doi.org/10.29352/mill0203.04.00114

López Miquel, J., & Martí Agustí G. (2011). Mini-Examen Cognoscitivo (MEC). Revista Española de Medicina Legal, 37(3), 122-127. https://doi.org/10.1016/S0377-4732(11)70075-X

Lorente Aznar, T., Olivera Pueyo, F. J., Benabarre Ciria, S., Rodríguez Torrente, M., Solans Aisa, B., Giménez Baratech, A. C. (2009). Rendimiento diagnóstico de los test cognitivos aplicados desde atención primaria. Concordancia y validez de los test de cribado. Atención Primaria, 42(4), 226-232. https://doi.org/10.1016/j.aprim.2009.07.014

Magaldi, D., & Berler, M. (2020). Semi-structured Interviews. In V. Zeigler-Hill & T. Shackelford (Eds.), Encyclopedia of Personality and Individual Differences (pp. 4825-4830). Springer. https://doi.org/10.1007/978-3-319-24612-3_857

Maggio, M. G., Billeri, L., Cardile, D., Quartarone, A., & Calabrò, R. S. (2024). The role of innovative technology in the rehabilitation of patients affected by Huntington's disease: A scoping review. Biomedicines, 12(1), 39. https://doi.org/10.3390/biomedicines12010039

Martínez Sánchez, I. (2023). Metodología cualitativa. En J. Quintanal Díaz y J. C. Sánchez-Huete (Coords.). Métodos y diseños de investigación en contextos socioeducativos (pp. 133-160). CCS.

Mejía Gallegos, A., García Tobon, M., Guamán Mariscal, E., & Murillo Brunes, A. (2024). La enfermedad de Huntington, síntomas y tratamiento. Journal of Science and Research, 9(1), 128-143. https://doi.org/10.5281/zenodo.10515711

Muñoz Marrón, E., De Noreña Martínez, D., & Sanz Cortes, A. (2017). Neuropsicología del daño cerebral adquirido. Traumatismos craneoencefálicos, accidentes cerebrovasculares y tumores del sistema nervioso central. UOC. https://shre.ink/jYKO

NeuronUP. (2024). Marco teórico y evidencia científica sobre cognición y neuropsicología. NeuronUP. https://shre.ink/jYKw

Parsons, M. P., & Raymond, L. A. (2023). Neurobiology of Huntington's disease. En Neurobiology of Brain Disorders (pp. 275-291). Elsevier. https://doi.org/10.1016/B978-0-323-85654-6.00042-3

Paz Sánchez, G. A (2024). Accidente cerebro vascular. En D. S. Ponce Miranda, G. A. Paz Sánchez, M. Quimbayo Polo, J. P., Acosta Dlyuz, H. A., Parrales Briones, E. F., Hualpa Galarza, B. S., Pazmiño Antepara, J. J., Tituana Moreira, J. A., Cusme Yagual, E. E., Pucuna Guapi, G. C., Villamar Flores, D., Flores Lucas, S., y Matute Solís, D. M. Actualización en Neurología Vol. 1. (pp. 27-50). Cuevas Editores SAS. https://doi.org/10.56470/978-9942-660-18-3

Petrozziello, T., Huntress, S., S. Castillo-Torres, A. L., Quinn, J. P., Connors, T. R., Auger, C. A., Mills, A. N., Kim, S. E., Liu, S., Mahmood, F., Boudi, A., Wu, M., Sapp, E., Kivisäkk, P., Sunderesh, S. R., Pouladi, M. A., Arnold, S. E., Hyman, B, T., Rosas, D. R., … & Sadri-Vakili, G. (2023). Age-dependent increase in tau phosphorylation at serine 396 in Huntington's disease pre-frontal cortex. Journal of Huntington's Disease, 12(3), 267-281. https://doi.org/10.3233/JHD-230588

Quinn, L., & Busse, M. (2017). Chapter 13 - The role of rehabilitation therapy in Huntington disease. Handbook of Clinical Neurology, 144, 151-65. https://doi.org/10.1016/B978-0-12-801893-4.00013-4

Rey-Fuentes. R. I., Jiménez-Maldonado, M. E., Arroyo-Medrano, M., & Villaseñor-Cabrera, T. (2021). El uso de programas computarizados y su efectividad en la rehabilitación de funciones ejecutivas en daño cerebral adquirido. Revista Ecuatoriana de Neurología, 30(1), 135-144. https://doi.org/10.46997/revecuatneurol30100135

Sánchez-Rojas, M., Puentes Rozo, P., Pineda, D. A., Acosta-López, J., Mejía-Segura, E., Cervantes-Henríquez, M., Martínez-Banfi, M., Ahmad, M., Ríos Anillo, M. R., Pineda-Alhucema, W., Noguera-Machacón, L. M., De la Hoz, M., Jiménez-Figueroa, G., Escudero-Cabarcas, J., Arcos-Burgos, M., Vélez, J. I., Montoya Grajeda, J., Rodríguez Gómez, O., Ruvalcaba Medina, A., … & Sánchez-Barrios, C. (2021). Enfermedad de Huntington: Una aproximación desde la investigación. Ediciones Universidad Simón Bolívar. https://doi.org/10.1007/978-628-7533-04-2

Sastre Barrios, C. (2020). Neurorrehabilitación y nuevas tecnologías. Revista Iberoamericana de Neuropsicología, 3(2), 157-170. https://neuropsychologylearning.com/wp-content/uploads/pdf/pdf-revista-vol3/vol3-n2-3.pdf

Vidal, C. (2017). Tratamiento neuropsicológico en la enfermedad de Huntington: Una revisión sistemática. Revista de Discapacidad y Neurociencias Clínicas, 4(1), 57-70. https://doi.org/10.14198/DCN.2017.4.1.05

World Medical Association (WMA) (2024). WMA Declaration of Helsinki – Ethical Principles for Medical Research Involving Human Subjects. https://www.wma.net/policies-post/wma-declaration-of-helsinki/

Xu, J. B. (2024). Conducting Semi-Structured Interviews in Social Service Research: A Practical Guide. National University of Singapore. https://shre.ink/jYCp

Downloads

Published

2026-07-03

How to Cite

Calvo Ortega, S., Fernández Hawrylak, M., & Varela Vázquez, C. (2026). Perception of the impact of NeuronUP in the cognitive rehabilitation of people with acquired brain injury and Huntington´ s disease. Millenium - Journal of Education, Technologies, and Health, 2(30), e47011. https://doi.org/10.29352/mill0230.47011

Issue

Section

Life and Healthcare Sciences