Lifestyle impact on serum level of vitamin D and PTH, in elderly
DOI:
https://doi.org/10.29352/mill0202.02.00125Keywords:
Institutionalization, 25-hydroxivitamin D3, 1, 25-dihydroxyvitamin D3, ParathormoneAbstract
Introduction: The aging process is responsible for health decline and may lead to the dependence and consequent institutionalization. Bone metabolism involves serum calcium regulators, such as vitamin D and PTH.
Objetives: The following study evaluated and compared serum concentrations of 25(OH)D and iPTH in elderly people living in institutions and living in their homes (free-living), with active and independent life.
Methods: We evaluated 50 elderly (25 institutionalized and 25 not institutionalized). We made an individual questionnaire and we collected blood to measured the serum concentrations of iPTH and 25(OH)D.
Results: Not institutionalized elderly showed higher 25(OH)D serum levels, comparing with institutionalized elderly (pvalue<0,05). The serum concentration of 25(OH)D was inversely correlated with iPTH. Furthermore calcium supplementation correlated with higher serum levels of 25(OH)D (p-value<0.05) and lower concentrations of iPTH (p-value<0,05). The free-living elderly who practice three or more activities per day, had higher concentrations of 25(OH)D (p-value<0.05) and lower concentrations of iPTH (p-value<0.05), compared to the institutionalized elderly. Outdoor activities showed also correlation with serum concentrations of both hormones (p-value<0.05).
Conclusion: The adoption of an active lifestyle and the contact with nature, carry profit to a better aging process.
Downloads
References
Analytics, Manual de ensaios do Advia centaur - Bula Vitamin D total (2010). Siemens Medical Solutions. 25, 1–5.
Boucher, B. J. (2012). The problems of vitamin d insufficiency in older people. Aging and Disease, 3(4), 313–329.
Castro, M., Camargos, S., Rodrigues, R. N., & Machado, C. J. (2011). Idoso , família e domicílio : uma revisão narrativa sobre a decisão de morar sozinho, 28(1), 217–230.
Ebeling, P. R. (2014). Vitamin D and bone health: Epidemiologic studies. BoneKEy Reports, 3(November 2013), 511. http://doi.org/10.1038/bonekey.2014.6
Gallagher, J. C., Kinyamu, H. K., Fowler, S. E., Dawson-Hughes, B., Dalsky, G. P., & Sherman, S. S. (1998). Calciotropic hormones and bone markers in the elderly. Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research, 13(3), 475–82. http://doi.org/10.1359/jbmr.1998.13.3.475
Himeno, M., Tsugawa, N., Kuwabara, A., Fujii, M., Kawai, N., Kato, Y., … Tanaka, K. (2009). Effect of vitamin D supplementation in the institutionalized elderly. Journal of Bone and Mineral Metabolism, 27(6), 733–7. http://doi.org/10.1007/s00774-009-0081-7
Instituto Nacional de Estatística (2014) População- Estatísticas Demográficas 2014. INE, Portugal (2014). Disponível em: http://www.ine.pt.
Kinyamu, H. K., Gallagher, J. C., Balhorn, K. E., Petranick, K. M., & Rafferty, K. A. (1997). Serum vitamin D metabolites and calcium absorption in normal young and elderly free-living women and in women living in nursing homes. The American Journal of Clinical Nutrition, 65(3).
Kinyamu, H. K., Gallagher, J. C., Rafferty, K. A., & Balhorn, K. E. (1998). Dietary calcium and vitamin D intake in elderly women : effect on serum parathyroid hormone and vitamin D metabolites. The American Journal of Clinical Nutrition 67(2), 342–348.
Kuwabara, A., Tsugawa, N., Tanaka, K., Fujii, M., Kawai, N., Mukae, S., Okano, T. (2009). Improvement of vitamin D status in Japanese institutionalized elderly by supplementation with 800 IU of vitamin D(3). Journal of Nutritional Science and Vitaminology, 55(6), 453–8. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/20086314
Laird, E., Ward, M., McSorley, E., Strain, J. J., & Wallace, J. (2010). Vitamin D and bone health: potential mechanisms. Nutrients, 2(7), 693–724. http://doi.org/10.3390/nu2070693
Lanham-new, S. A. (2008). Importance of calcium , vitamin D and vitamin K for osteoporosis prevention and treatment, (July 2007), 163–176. http://doi.org/10.1017/S0029665108007003
Lips, P. (2012). Interaction between vitamin D and calcium. Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum, 243(Suppl 243), 60–4. http://doi.org/10.3109/00365513.2012.681960
Marisa, H., & Neves, F. (2012). Causas e Consequências da Institucionalização de Idosos - Estudo tipo série de casos. Dissertação de Mestrado em Gerontologia. Universidade da Beira Interior - Ciências da Saúde. Disponivel em: https://ubibliorum.ubi.pt/bitstream/10400.6/1209/1/CAUSAS_CONSEQUENCIAS_INSTITUCIONALIZA%C3%87AO_IDOSOS.pdf
Marta, S., & Cardoso, R. (1998). Vitamina D em idosos (Tese de douturamento não publicada). Faculdade de Ciências da Nutrição e Alimentação da Universidades do Porto.
Paula, M., Sequeira, R., & Dias, M. O. (2011). Adaptação dos idosos institucionalizados. Millenium, 40: 161–184. Disponivel em: www.ipv.pt/millenium/Millenium40/12.pdf.
Pérez-llamas, F., Ph, D., López-contreras, M. J., Ph, D., Blanco, M. J., Ph, D., … Ph, D. (2008). Seemingly paradoxical seasonal influences on vitamin D status in nursing-home elderly people from a Mediterranean area, 24, 414–420. http://doi.org/10.1016/j.nut.2008.01.006
Instituto Nacional de Estatística (2014) População- Estatísticas Demográficas 2014. INE, Portugal (2014). Disponível em: http://www.ine.pt.
Portela, M. L. P. M., Mónico, A., Barahona, A., Dupraz, H., Sol Gonzales-Chaves, M. M., & Zeni, S. N. (2010). Comparative 25-OHvitamin D level in institutionalized women older than 65 years from two cities in Spain and Argentina having a similar
solar radiation index. Nutrition (Burbank, Los Angeles County, Calif.), 26(3), 283–9. http://doi.org/10.1016/j.nut.2009.04.022
PTH Intacta, Manual de ensaios do Advia Centaur (2007). Bula PTH intacta (iPTH). Siemens Medical Solutions Diagnostics. 1-12.
Santiago, T., Rebelo, M., Porto, J., Silva, N., Vieira, J., & Costa, J. M. N. (2012). Hipovitaminose D em Doentes Internados num Serviço de Medicina Interna, 25(2), 68–76.
Saraiva, G. L., Cendoroglo, M. S., Ramos, L. R., Araújo, L. M. Q., Vieira, J. G. H., Maeda, S. S., … Lazaretti-Castro, M. (2007).Prevalência da deficiência, insuficiência de vitamina D e hiperparatiroidismo secundário em idosos institucionalizados e
moradores na comunidade da cidade de São Paulo, Brasil. Arquivos Brasileiros de Endocrinologia & Metabologia, 51, 437–442. http://doi.org/10.1590/S0004-27302007000300012
Silva, B. C. C., Camargos, B. M., Fujii, J. B., Dias, E. P., & Soares, M. M. S. (2008). Prevalência de deficiência e insuficiência de vitamina D e sua correlação com PTH, marcadores de remodelação óssea e densidade mineral óssea, em pacientes
ambulatoriais. Arquivos Brasileiros de Endocrinologia & Metabologia, 52(3), 482–488. http://doi.org/10.1590/S0004-27302008000300008
Suleiman, S., Nelson, M., Li, F., & Moniz, C. (1997). Effect of calcium intake and physical activity levei on bone mass and turnover in healthy , white , postmenopausal women. The American Journal of Clinical Nutrition, 66(4).
Thacher, T. D., & Clarke, B. L. (2011). Vitamin D insufficiency. Mayo Clinic Proceedings. Mayo Clinic, 86(1), 50–60. http://doi.org/10.4065/mcp.2010.0567
Timpini, A., Pini, L., Tantucci, C., Cossi, S., & Grassi, V. (2011). Vitamin D and health status in elderly. Internal and Emergency Medicine, 6(1), 11–21. http://doi.org/10.1007/s11739-010-0407-4
World Health Organization. (2005). Envelhecimento ativo: uma política de saúde, 60. Retrieved from http://scholar.google.com/scholar?hl=en&btnG=Search&q=intitle:Envelhecimento+ativo:+uma+pol?tica+de+sa?de#0
Downloads
How to Cite
Issue
Section
License
Authors who submit proposals for this journal agree to the following terms:
a) Articles are published under the Licença Creative Commons (CC BY 4.0), in full open-access, without any cost or fees of any kind to the author or the reader;
b) The authors retain copyright and grant the journal right of first publication, allowing the free sharing of work, provided it is correctly attributed the authorship and initial publication in this journal;
c) The authors are permitted to take on additional contracts separately for non-exclusive distribution of the version of the work published in this journal (eg, post it to an institutional repository or as a book), with an acknowledgment of its initial publication in this journal;
d) Authors are permitted and encouraged to publish and distribute their work online (eg, in institutional repositories or on their website) as it can lead to productive exchanges, as well as increase the impact and citation of published work
Documents required for submission
Article template (Editable format)