Ozone therapy as a coadjuvant in wound healing and pain reduction

Authors

  • Célia Mendes Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal https://orcid.org/0000-0001-6987-2358
  • Madalena Cunha Instituto Politécnico de Viseu, Escola Superior de Saúde, Viseu, Portugal | UICISA:E, ESEnfC, Coimbra / SIGMA – Phi Xi Chapter, ESEnfC, Coimbra, Portugal | CIEC - UM, Braga, Portugal https://orcid.org/0000-0003-0710-9220
  • Ana Ferreira Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal https://orcid.org/0000-0002-1857-7786
  • Eduardo Santos Health School of the Polytechnic Institute of Viseu, Viseu, Portugal | Health Sciences Research Unit: Nursing (UICISA:E), Nursing School of Coimbra, Coimbra, Portugal https://orcid.org/0000-0003-0557-2377

DOI:

https://doi.org/10.29352/mill029e.25237

Keywords:

ozone, wound healing, pain, wounds and injuri

Abstract

Introduction: Ozone is considered a potent antimicrobial agent and is therefore used as a complementary therapy for wound healing and pain reduction. However, this subject is still little empirically studied.

Objetive: To analyse the therapeutic capacity of ozone therapy as an adjuvant in wound healing and pain reduction.

Methods: This was an exploratory, cross-sectional, retrospective, and descriptive study. Data analysis was based on descriptive and inferential statistics using the Mann-Whitney and Friedman tests (continuous data) and the Chi-square/Fisher test (dichotomous or ordinal data).

Results: Twenty people were included, mostly females (55%) and with a mean age of 61.9 years (±16.7). A more aggravated state of healing and higher levels of initial pain were associated to non-healing (p=0.02; p=0.03, respectively). Regarding the time evolution of wound healing and pain levels (baseline, 1st month, 2nd month and 3rd month) a gradual reduction of values was observed, which reflects a significant improvement of healing and pain reduction. Healing did not occur in only 35% (n=7) of the cases.

Conclusion: Ozone therapy improved wound healing and reduced the associated pain levels. However, given the small sample size, it is necessary to replicate the study in larger samples and with diversified nosological entities to validate the benefits of this therapeutic intervention.

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References

Degli Agosti, I., Ginelli, E., Mazzacane, B., Peroni, G., Bianco, S., Guerriero, F., Ricevuti, G., Perna, S., & Rondanelli, M. (2016). Effectiveness of a Short-Term Treatment of Oxygen-Ozone Therapy into Healing in a Posttraumatic Wound. Case reports in medicine, 9528572-9528572. https://doi.org/10.1155/2016/9528572

Direção-Geral da Saúde. (2003). A Dor como 5º sinal vital - Registo sistemático da intensidade da Dor. Circular Normativa nº 9/DGCG de 14/6/2003.

Elvis, A. M., & Ekta, J. S. (2011). Ozone therapy: A clinical review. Journal of natural science, biology, and medicine, 2(1), 66-70. https://doi.org/10.4103/0976-9668.82319

Esteves, E. S. (2017). Eficácia da ozonoterapia tópica na redução da carga bacteriana e tempo de cicatrização em úlceras de etiologia venosa dos membros inferiores. Dissertação de Mestrado. Escola Superior de Saúde de Viseu. http://hdl.handle.net/10400.19/4533

Ferreira, P. L., Miguéns, C., Gouveia, J., & Furtado, K. (2007). Medição da qualidade de vida de doentes com feridas crónicas: a Escala de Cicatrização da Úlcera de Pressão e o Esquema de Cardiff de Impacto da Ferida. Nursing, 221, 32-41.

Fitzpatrick, E., Holland, O. J., & Vanderlelie, J. J. (2018). Ozone therapy for the treatment of chronic wounds: A systematic review. Int Wound J, 15(4), 633-644. https://doi.org/https://doi.org/10.1111/iwj.12907

Iorio, M. L., Shuck, J., & Attinger, C. E. (2012). Wound healing in the upper and lower extremities: a systematic review on the use of acellular dermal matrices. Plastic and reconstructive surgery, 130(5 Suppl 2), 232S–241S.

Landén, N. X., Li, D., & Ståhle, M. (2016). Transition from inflammation to proliferation: a critical step during wound healing. Cellular and molecular life sciences : CMLS, 73(20), 3861–3885. https://doi.org/10.1007/s00018-016-2268-0.

Liu, J., Zhang, P., Tian, J., Li, L., Li, J., Tian, J. H., & Yang, K. (2015). Ozone therapy for treating foot ulcers in people with diabetes. The Cochrane database of systematic reviews, 2015(10), CD008474. https://doi.org/10.1002/14651858.CD008474.pub2

Marchesini, B. F., & Ribeiro, S. B. (2020). Efeito da ozonioterapia na cicatrização de feridas. Fisioterapia Brasil, 21(3), 281–288. https://doi.org/https://doi.org/10.33233/fb.v21i3.2931

Mota, M., Cunha, M., Santos, M. R., Duarte, J., Rocha, A . R., Rodrigues, A., Gonçalves, C., Ribeiro, R., Sobreira, S., & Pereira, S. (2020). Gestão da dor na prática de enfermagem no serviço de urgência. Millenium, 2(ed espec nº5), 269-279. DOI: https://doi.org/10.29352/mill0205e.29.00257

Paschou, S. A., Stamou, M., Vuagnat, H., Tentolouris, N., & Jude, E. (2018). Pain management of chronic wounds: Diabetic ulcers and beyond. Maturitas, 117, 17–21. https://doi.org/10.1016/j.maturitas.2018.08.013

Pechersky, A. V., Pechersky, V. I., Shpilenya, E. S., Gaziev, A. H., & Semiglazov, V. F. (2016). Regeneration and Cicatrization. Journal of stem cells, 11(2), 89–97.

Pestana, M. G., & Gageiro, J. N. (2008). Análise de Dados para Ciências Sociais. A complementaridade do SPSS. 5ª edição revista e corrigida. Lisboa, Edições Sílabo, pp. 527-528.

Portaria n.º 163/2013 de 24 de abril. Diário da República n.º 80/2013, Série I de 2013-04-24. Ministério da Saúde.

Santos, J. L. P. dos. (2016). Necessidades formativas dos enfermeiros portugueses em ozonoterapia. Dissertação de Mestrado. Instituto Superior de Educação e Ciências de Lisboa. http://hdl.handle.net/10400.26/21816

Shah, P., Shyam, A. K., & Shah, S. (2011). Adjuvant combined ozone therapy for extensive wound over tibia. Indian journal of orthopaedics, 45(4), 376–379. https://doi.org/10.4103/0019-5413.80332

Smith, N. L., Wilson, A. L., Gandhi, J., Vatsia, S., & Khan, S. A. (2017). Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility. Medical gas research, 7(3), 212–219. https://doi.org/10.4103/2045-9912.215752

Sorg, H., Tilkorn, D. J., Hager, S., Hauser, J., & Mirastschijski, U. (2017). Skin Wound Healing: An Update on the Current Knowledge and Concepts. European Surgical Research, 58(1-2), 81-94. https://doi.org/10.1159/000454919

Wilcox, C. E., Mayer, A. R., Teshiba, T. M., Ling, J., Smith, B. W., Wilcox, G. L., & Mullins, P. G. (2015). The Subjective Experience of Pain: An FMRI Study of Percept-Related Models and Functional Connectivity. Pain medicine (Malden, Mass.), 16(11), 2121–2133. https://doi.org/10.1111/pme.12785

Published

2021-11-30

How to Cite

Mendes, C., Cunha, M., Ferreira, A., & Santos, E. (2021). Ozone therapy as a coadjuvant in wound healing and pain reduction . Millenium - Journal of Education, Technologies, and Health, 2(9e), 131–138. https://doi.org/10.29352/mill029e.25237

Issue

Section

Life and Healthcare Sciences