Non-invasive mechanical ventilation in severe acute respiratory syndrome in patients hospitalized for COVID-19

systematic review protocol




COVID-19, non-invasive ventilation, hospitalization


Introduction: Non-Invasive Ventilation is a form of ventilatory support that promotes improvement in several respiratory parameters such as peripheral oxygen saturation, decreased respiratory work, and a significant reduction in the need for intubation and mortality. It is a widely used therapy in the treatment of severe hypoxemia and refractory to oxygen therapy, a clinical condition observed in patients hospitalized for COVID-19.

Objective: Investigate through the scientific literature the interference of Non-Invasive Ventilation in the hospital outcome of patients with severe acute respiratory syndrome triggered by COVID-19.

Methods: The review will follow the guidelines established by the Joanna Briggs Institute methodology and Preferred Report Items for Systematic Reviews and Meta-Analyses. Two independent reviewers will perform the search, quality assessment, data extraction, and synthesis. The databases used will be PubMed, PEDro, Cochrane Central Register of Controlled Trials, Scielo, and Web of Science. Also, studies published in the grey literature in ProQuest Disserts and Theses Database Science and Google Scholar that meet established criteria will be included.

Results: An initial survey showed that the proper use of Non-Invasive Ventilation administered with a helmet has significant outcomes on the rate of Orotracheal Intubation and Invasive Mechanical Ventilation. There were also studies with outcomes on morbidity and mortality and protocols for use and monitoring.

Conclusion: The results will inform the use of this therapy and its outcomes to promote an effective intervention in hospitalized patients.


Download data is not yet available.


Brugge, S., Talman, S., Boonman-de Winter, L., de Mol, M., Hoefman, E., van Etten, R. W., & De Backer, I. C. (2021). Pulmonary function and health-related quality of life after COVID-19 pneumonia. Respiratory Medicine, 176, 106272.

Duan, J., Han, X., Bai, L., Zhou, L., & Huang, S. (2017). Assessment of heart rate, acidosis, consciousness, oxygenation, and respiratory rate to predict noninvasive ventilation failure in hypoxemic patients. Intensive Care Medicine, 43(2), 192–199.

Gavriatopoulou, M., Ntanasis-Stathopoulos, I., Korompoki, E., Fotiou, D., Migkou, M., Tzanninis, I.-G., Psaltopoulou, T., Kastritis, E., Terpos, E., & Dimopoulos, M. A. (2021). Emerging treatment strategies for COVID-19 infection. Clinical and Experimental Medicine, 21(2), 167–179.

González-Castro, A., Fajardo Campoverde, A., Medina, A., & Alapont, V. (2021). Ventilación mecánica no invasiva y oxigenoterapia de alto flujo en la pandemia COVID-19: El valor de un empate. [Non-invasive mechanical ventilation and high-flow oxygen therapy in the COVID-19 pandemic: the value of a draw]. Medicina intensiva, 45(5), 320–321.

Grieco, D. L., Menga, L. S., Cesarano, M., Rosà, T., Spadaro, S., Bitondo, M. M., Montomoli, J., Falò, G., Tonetti, T., Cutuli, S. L., Pintaudi, G., Tanzarella, E. S., Piervincenzi, E., Bongiovanni, F., Dell’Anna, A. M., Delle Cese, L., Berardi, C., Carelli, S., Bocci, M. G., … COVID-ICU Gemelli Study Group. (2021). Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical Trial. JAMA, 325(17), 1731–1743.

Guia, M. F., Boléo-Tomé, J. P., Imitazione, P., Polistina, G. E., Alves, C., Ishikawa, O., Ballenberger, M., Mina, B., Fiorentino, G., Esquinas, A., & Scala, R. (2021). Usefulness of the HACOR score in predicting success of CPAP in COVID-19-related hypoxemia. Respiratory Medicine, 187, 106550.

Hraiech, S., Alingrin, J., Dizier, S., Brunet, J., Forel, J.-M., La Scola, B., Roch, A., Papazian, L., & Pauly, V. (2013). Time to Intubation Is Associated with Outcome in Patients with Community-Acquired Pneumonia. PLoS ONE, 8(9), e74937.

Mohamed, A. A., & Alawna, M. (2020). Role of increasing the aerobic capacity on improving the function of immune and respiratory systems in patients with coronavirus (COVID-19): A review. Diabetes & Metabolic Syndrome, 14(4), 489–496.

Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & PRISMA Group. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Medicine, 6(7), e1000097.

Murthy, S., Gomersall, C. D., & Fowler, R. A. (2020). Care for Critically Ill Patients With COVID-19. JAMA, 323(15), 1499–1500.

Nava, S., Schreiber, A., & Domenighetti, G. (2011). Noninvasive ventilation for patients with acute lung injury or acute respiratory distress syndrome. Respiratory Care, 56(10), 1583–1588.

Navarra, S. M., Congedo, M. T., & Pennisi, M. A. (2020). Indications for Non-Invasive Ventilation in Respiratory Failure. Reviews on Recent Clinical Trials, 15(4), 251–257.

Osadnik, C. R., Tee, V. S., Carson‐Chahhoud, K. V., Picot, J., Wedzicha, J. A., & Smith, B. J. (2017). Non‐invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease. The Cochrane Database of Systematic Reviews, 2017(7), CD004104.

Peters, M.D.J., Godfrey, C., McInerney, P., Munn, Z., Tricco, A.C., & Khalil, H. (2020). Chapter 11: Scoping Reviews (2020 version). In: Aromataris E., & Munn Z. (Edits.). JBI Manual for Evidence Synthesis. Joanna Briggs Institute Reviewer's Manual. Available from

Polak, S. B., Van Gool, I. C., Cohen, D., von der Thüsen, J. H., & van Paassen, J. (2020). A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression. Modern Pathology, 33(11), 2128–2138.

Sharma, A., Ahmad Farouk, I., & Lal, S. K. (2021). COVID-19: A Review on the Novel Coronavirus Disease Evolution, Transmission, Detection, Control and Prevention. Viruses, 13(2), 202.

Schünemann, H. J., Guyatt, G., Oxman, A. D., Akl, E. A., Kunz, R., Vist, G., Brozek, J., Norris, S., Falck-Ytter, Y., Glasziou, P., deBeer, H., Jaeschke, R., Rind, D., Meerpohl, J., & Dahm, P. (2013). Handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach (Vol. 64). The GRADE Working Group.

Spadari, J. A. A., & Gardenghi, G. (2020). Aspectos fisiopatológicos do COVID-19 e uso de ventilação não invasiva. É possível? Revista Pesquisa em Fisioterapia, 10(3), 372–375.

Sullivan, Z. P., Zazzeron, L., Berra, L., Hess, D. R., Bittner, E. A., & Chang, M. G. (2022). Noninvasive respiratory support for COVID-19 patients: When, for whom, and how? Journal of Intensive Care, 10(1), 3.

Wang, Z., Wang, Y., Yang, Z., Wu, H., Liang, J., Liang, H., Lin, H., Chen, R., Ou, Y., Wang, F., Wang, Y., Wang, Y., Luo, W., Li, N., Li, Z., Xie, J., Jiang, M., & Li, S. (2021). The use of non-invasive ventilation in COVID-19: A systematic review. International Journal of Infectious Diseases: IJID: Official Publication of the International Society for Infectious Diseases, 106, 254–261.

Wendel-Garcia, P. D., Mas, A., González-Isern, C., Ferrer, R., Máñez, R., Masclans, J.-R., Sandoval, E., Vera, P., Trenado, J., Fernández, R., Sirvent, J.-M., Martínez, M., Ibarz, M., Garro, P., Lopera, J. L., Bodí, M., Yébenes-Reyes, J. C., Triginer, C., Vallverdú, I., … UCIsCAT study group. (2022). Non-invasive oxygenation support in acutely hypoxemic COVID-19 patients admitted to the ICU: A multicenter observational retrospective study. Critical Care, 26(1), 37.

Weng, C.-L., Zhao, Y.-T., Liu, Q.-H., Fu, C.-J., Sun, F., Ma, Y.-L., Chen, Y.-W., & He, Q.-Y. (2010). Meta-analysis: Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema. Annals of Internal Medicine, 152(9), 590–600.

Windisch, W., Weber-Carstens, S., Kluge, S., Rossaint, R., Welte, T., & Karagiannidis, C. (2020). Invasive and Non-Invasive Ventilation in Patients With COVID-19. Deutsches Ärzteblatt International, 117(31–32), 528–533.

Yilma, M., Taye, G., Kifle, A., Ayele, W., & Biruk, E. (2021). Hospitalization, Recovery, Death, incubation period and Severity of COVID-19: A Systematic Review. Ethiopian Journal of Health Development, 35(1), Article 1.

Zhan, Q., Sun, B., Liang, L., Yan, X., Zhang, L., Yang, J., Wang, L., Ma, Z., Shi, L., Wei, L., Li, G., Yang, L., Shi, Z., Chen, Y., Xu, Q., Li, W., Zhu, X., Wang, Z., Sun, Y., … Wang, C. (2012). Early use of noninvasive positive pressure ventilation for acute lung injury: A multicenter randomized controlled trial. Critical Care Medicine, 40(2), 455–460.




How to Cite

Cirilo, S. S. V., Machado, R. da S., Santos, A. da C., Rodrigues, K. L., & Silva, B. A. K. da. (2022). Non-invasive mechanical ventilation in severe acute respiratory syndrome in patients hospitalized for COVID-19: systematic review protocol . Millenium - Journal of Education, Technologies, and Health, 2(19), 63–69.



Life and Healthcare Sciences