The possible impact of pre-transfusion laboratory interference
DOI:
https://doi.org/10.29352/mill0216e.36799Keywords:
laboratory interference; therapeutic plasmapheresis; crossmatch; transfusionAbstract
Introduction: Pre-transfusion tests allow the detection of clinically significant antibodies and the prior compatibility of units to be transfused.
Objective: To describe a clinical case treated with plasmapheresis and immunosuppression.
Methods: Descriptive study of a clinical case of a 55-year-old man, hospitalized for rapidly progressive renal failure, treated with plasmapheresis and immunosuppression to reduce/remove the pathological immune component responsible for interfering with pre-transfusion tests. Daily monitoring of the clinical situation was carried out using laboratory tests of specific blood parameters.
Results: The decrease in antibody titters, due to the action of the immunosuppressants used in association with the TPE sessions, in addition to the clear clinical impact on the recovery of renal function, also made it possible to remove this interference and select the blood units more safely.
Conclusion: It is essential to develop methods that identify and remove pathological substances that could interfere with the compatibility of units to be transfused and, therefore, with transfusion safety.
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Connelly-Smith, L., Alquist, C. R., Aqui, N. A., Hofmann, J. C., Klingel, R., Onwuemene, O. A., Patriquin, C. J., Pham, H. P., Sanchez, A. P., Schneiderman, J., Witt, V., Zantek, N. D., & Dunbar, N. M. (2023). Guidelines on the Use of Therapeutic Apheresis in Clinical Practice - Evidence-Based Approach from the Writing Committee of the American Society for Apheresis: The Ninth Special Issue. Journal of Clinical Apheresis, 38(2), 77–278. https://doi.org/10.1002/jca.22043
Harmening, D. (2019). Modern Blood Banking & Transfusion Practices, 7thedition. F.A. Davis.
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