Benefits of blood product administration in major trauma victims in prehospital care: scoping review
DOI:
https://doi.org/10.29352/mill0223e.43837Keywords:
blood component transfusion; blood transfusion; multiple trauma; wounds and injuries; prehospital careAbstract
Introduction: Trauma is a global public health problem, with a high mortality rate and decreased quality of life. In victims of major trauma, hemorrhagic shock represents one of the main causes of death in prehospital settings, highlighting the importance of administering blood products.
Objective: To map the benefits of administering blood products to victims of major trauma in prehospital settings.
Methods: Scoping review according to the Joanna Briggs Institute methodology using the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for scoping review flowchart. The CINAHL, MEDLINE, PubMed, and LILACS databases were searched. Quantitative and qualitative studies, as well as other scoping reviews, were considered.
Results: The administration of blood products in prehospital settings in victims of major trauma is associated with increased survival, reduced mortality, and better hemodynamic stabilization; reduced time to first transfusion; effective control over the components of the lethal diamond (coagulopathy, acidosis, hypothermia, and hypocalcemia); reduced volume of crystalloid usage, as well as the optimization of hospital and transfusion resources.
Conclusion: The results support the integration of blood product administration into protocols for managing victims of major trauma in prehospital settings.
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Allon, R., Epstein, D., & Shavit, I. (2020). Prehospital transfusion of low-titer cold-stored whole blood through the intraosseous route in a trauma patient with hemorrhagic shock. Transfusion, 60(4), 875–878. https://doi.org/10.1111/trf.15732
Anto, V. P., Guyette, F. X., Brown, J., Daley, B., Miller, R., Harbrecht, B., Claridge, J., Phelan, H., Neal, M., Forsythe, R., Zuckerbraun, B., & Sperry, J. (2020). Severity of hemorrhage and the survival benefit associated with plasma: Results from a randomized prehospital plasma trial. Journal of Trauma and Acute Care Surgery, 88(1), 141–147. https://doi.org/10.1097/TA.0000000000002530
Carico, C., Annesi, C., Mann, N. C., Levy, M. J., Acharya, P., Hurson, T., Lammers, D., Jansen, J. O., Kerby, J. D., Holcomb, J. B., & Hashmi, Z. G. (2025). Nationwide trends in prehospital blood product use after injury 2020–2023. Transfusion, 65, 30–39. https://doi.org/10.1111/trf.18221
Chapman, M. P., Moore, E. E., Chin, T. L., Ghasabyan, A., Chandler, J., Stringham, J., Gonzalez, E., Moore, H. B., Banerjee, A., Silliman, C., & Sauaia, A. (2015). COMBAT: Initial experience with a randomized clinical trial of plasma-based resuscitation in the field for traumatic hemorrhagic shock. Shock, 44(Suppl. 1), 63–70. https://doi.org/10.1097/SHK.0000000000000376
Committee on Military Trauma Care’s Learning Health System and Its Translation to the Civilian Sector, Board on Health Sciences Policy, Board on the Health of Select Populations, Health and Medicine Division, & National Academies of Sciences, Engineering, and Medicine. (2016). A national trauma care system: Integrating military and civilian trauma systems to achieve zero preventable deaths after injury. National Academies Press. https://www.ncbi.nlm.nih.gov/books/NBK390321/
Direção-Geral da Saúde. (2022). Norma n.º 012/2022 de 18/11/2022: Via verde do trauma no adulto. https://shre.ink/77gp
Dudaryk, R., Heim, C., Ruetzler, K., & Pivalizza, E. G. (2022). Pro-con debate: Prehospital blood transfusion—Should it be adopted for civilian trauma? Anesthesia & Analgesia, 134(4), 678–682. https://doi.org/10.1213/ANE.0000000000005747
Eurostat. (2024). Accidents and injuries statistics. https://shre.ink/77gW
Giacometto, P., Aboboreira, M., Massago, M., & Andrade, L. (2024). Segurança da transfusão de sangue na cena pelo Serviço extra-hospitalar de Ambulância: Um estudo de caso na Macrorregião Noroeste do Paraná. Hematology, Transfusion and Cell Therapy, 46(Suppl.), S837. https://doi.org/10.1016/j.htct.2024.09.1419
Gruen, D. S., Brown, J. B., Guyette, F. X., Vodovotz, Y., Johansson, P. I., Stensballe, J., Barclay, D. A., Yin, J., Daley, B. J., Miller, R. S., Harbrecht, B. G., Claridge, J. A., Phelan, H. A., Neal, M. D., Zuckerbraun, B. S., Billiar, T. R., & Sperry, J. L. (2020a). Prehospital plasma is associated with distinct biomarker expression following injury. The Journal of Clinical Investigation Insight, 5(8). https://doi.org/10.1172/jci.insight.135350
Gruen, D. S., Guyette, F. X., Brown, J. B., Daley, B. J., Miller, R. S., Harbrecht, B. G., Claridge, J. A., Phelan, H. A., Yazer, M. H., Neal, M. D., Zuckerbraun, B. S., & Sperry, J. L. (2020b). Characterization of unexpected survivors following a prehospital plasma randomized trial. Journal of Trauma and Acute Care Surgery, 89(5), 908–914. https://doi.org/10.1097/TA.0000000000002816
Guyette, F. X., Sperry, J. L., Peitzman, A. B., Billiar, T. R., Daley, B. J., Miller, R. S., Harbrecht, B. G., Claridge, J. A., Putnam, T., Duane, T. M., Phelan, H. A., & Brown, J. B. (2021). Prehospital blood product and crystalloid resuscitation in the severely injured patient: A secondary analysis of the prehospital air medical plasma trial. Annals of Surgery, 273(2), 10–17. https://doi.org/10.1097/SLA.0000000000003324
Hamed, A. A., Shuib, S. M., Elhusein, A. M., Fadlalmola, H. A., Higazy, O. A., Mohammed, I. H., Mohamed, B. S., Abdelmalik, M., Al-Sayaghi, K. M., Saeed, A. A. M., Hegazy, S. M., Albalawi, S., Alrashidi, A., & Abdallah, M. (2024). Efficacy and safety of prehospital blood transfusion in traumatized patients: A systematic review and meta-analysis. Prehospital and Disaster Medicine, 39(5), 1–11. https://doi.org/10.1017/S1049023X24000621
Kim, B. D., Zielinski, M. D., Jenkins, D. H., Schiller, H. J., Berns, K. S., & Zietlow, S. P. (2012). The effects of prehospital plasma on patients with injury. Journal of Trauma and Acute Care Surgery, 73(2), S49–S53. https://doi.org/10.1097/TA.0b013e31826060ff
Lammers, D. T., Betzold, R., Henry, R., Dilday, J., Conner, J. R., Williams, J. M., McClellan, J. M., Eckert, M. J., Jansen, J. O., Kerby, J., Holcomb, J. B., & Hashmi, Z. G. (2025). Nationwide estimates of potential lives saved with prehospital blood transfusions. Transfusion, 65, 14–22. https://doi.org/10.1111/trf.18174
Marsden, M. E. R., Kellett, S., Bagga, R., et al. (2023). Understanding pre-hospital blood transfusion decision-making for injured patients: An interview study. Emergency Medicine Journal, 40, 777–784. https://doi.org/10.1136/emermed-2023-213086
O’Reilly, D. J., Morrison, J. J., Jansen, J. O., Apodaca, A. N., Rasmussen, T. E., & Midwinter, M. J. (2014). Prehospital blood transfusion in the en route management of severe combat trauma. Journal of Trauma and Acute Care Surgery, 77(3), S114–S120. https://doi.org/10.1097/TA.0000000000000328
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., … Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71. https://doi.org/10.1136/bmj.n71
Pusateri, A. E., Moore, E. E., Moore, H. B., Le, T. D., Guyette, F. X., Chapman, M. P., Sauaia, A., Ghasabyan, A., Chandler, J., McVaney, K., Brown, J.B., Daley, B.J., Miller, R.S., Harbrecht, B.G., Claridge, J.A., Phelan, H.A., Witham, W.R., Putman, A.T., & Sperry, J. L. (2020). Association of prehospital plasma transfusion with survival in trauma patients with hemorrhagic shock when transport times are longer than 20 minutes. JAMA Surgery, 155(2), e195085. https://doi.org/10.1001/jamasurg.2019.5085
Rehn, M., Weaver, A. E., Eshelby, S., Røislien, J., & Lockey, D. J. (2017). Pre-hospital transfusion of red blood cells in civilian trauma patients. Transfusion Medicine, 28(4), 277–283. https://doi.org/10.1111/tme.12483
Reitz, K. M., Moore, H. B., Guyette, F. X., Sauaia, A., Pusateri, A. E., Moore, E. E., Hassoune, A., Chapman, M.P., Daley, B.J., Miller, R.S., Harbrecht, B.G., Claridge, J.A., Phelan, H.A., Brown, J.B., Zuckerbraun, B.S., Neal, M.D., Yazer, M.H., & Sperry, J.L. (2020). Prehospital plasma in injured patients is associated with survival principally in blunt injury. Journal of Trauma and Acute Care Surgery, 88(1), 33–41. https://doi.org/10.1097/TA.0000000000002485
Rijnhout, T. W. H., Wever, K. E., Marinus, R. H. A. R., Hoogerwerf, N., Geeraedts, L. M. G., & Tan, E. C. T. H. (2019). Is prehospital blood transfusion effective and safe in haemorrhagic trauma patients? A systematic review and meta-analysis. Injury, 50(5), 1017–1027. https://doi.org/10.1016/j.injury.2019.03.033
Rito, S., Ferreira, R. J. O., Marques, N., Frutuoso, A., & Baptista, R. (2024). Tempos de resposta e intervenções extra-hospitalares à vítima de trauma major na Região Centro de Portugal: Um estudo retrospetivo. Acta Médica Portuguesa, 37(7–8), 526–534. https://doi.org/10.20344/amp.20983
Rossaint, R., Afshari, A., Bouillon, B., Cerny, V., Cimpoesu, D., Curry, N., Duranteau, J., Filipescu, D., Grottke, O., Grønlykke, L., Harrois, A., Hunt, B. J., Kaserer, A., Komadina, R., Madsen, M.H., Maegele, M., Mora, L., Riddez, L., Romero, C.S., Samama, C-M., & Spahn, D. R. (2023). The European guideline on management of major bleeding and coagulopathy following trauma: Sixth edition. Critical Care, 27, 80. https://doi.org/10.1186/s13054-023-04327-7
Seheult, J. N., Stram, M. N., Sperry, J., Spinella, P. C., Triulzi, D. J., & Yazer, M. H. (2018). In silico model of the dilutional effects of conventional component therapy versus whole blood in the management of massively bleeding adult trauma patients. Transfusion, 59(1), 146–158. https://doi.org/10.1111/trf.14983
Shackelford, S. A., Del Junco, D. J., Powell-Dunford, N., Mazuchowski, E. L., Howard, J. T., Kotwal, R. S., Gurney, J., Butler, F. K., Gross, K., & Stockinger, Z. T. (2017). Association of prehospital blood product transfusion during medical evacuation of combat casualties in Afghanistan with acute and 30-day survival. JAMA, 318(16), 1581–1591. https://doi.org/10.1001/jama.2017.15097
Society of Trauma Nurses. (2023). Position statement on qualifications and competencies for the trauma program manager. Journal of Trauma Nursing, 30(5), 251–254. https://doi.org/10.1097/JTN.0000000000000738
Sperry, J. L., Guyette, F. X., Brown, J. B., Yazer, M. H., Triulzi, D. J., Early-Young, B. J., … Rosengart, M. R. (2018). Prehospital plasma during air medical transport in trauma patients at risk for hemorrhagic shock. New England Journal of Medicine, 379(4), 315–326. https://doi.org/10.1056/NEJMoa1802345
Stubbs, J. R., Zielinski, M. D., Berns, K. S., Badjie, K. S., Tauscher, C. D., Hammel, S. A., Zietlow, S. P., & Jenkins, D. (2015). How we provide thawed plasma for trauma patients. Transfusion, 55(8), 1830–1837. https://doi.org/10.1111/trf.13156
Thies, K.-C., Truhlář, A., Keene, D., Hinkelbein, J., Rützler, K., Brazzi, L., & Vivien, B. (2020). Pre-hospital blood transfusion: An ESA survey of European practice. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 28(1). https://doi.org/10.1186/s13049-020-00774-1
Tricco, A. C., Lillie, E., Zarin, W., O’Brien, K. K., Colquhoun, H., Levac, D., Moher, D., Peters, M. D. J., Horsley, T., Weeks, L., Hempel, S., Akl, E. A., Chang, C., McGowan, J., Stewart, L., Hartling, L., Aldcroft, A., Wilson, M. G., Garritty, C., … Straus, S. E. (2018). PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Annals of Internal Medicine, 169(7), 467–473. https://doi.org/10.7326/M18-0850
Yazer, M. H., Jenkins, D. H., Sperry, J. L., & Spinella, P. C. (2022). How do we forecast tomorrow’s transfusion? Prehospital transfusion. Transfusion Clinique et Biologique, 30(1), 39–42. https://doi.org/10.1016/j.tracli.2022.07.007
Yazer, M. H., Spinella, P. C., Bank, E. A., Cannon, J. W., Dunbar, N. M., Holcomb, J. B., Jackson, B. P., Jenkins, D., Levy, M., Pepe, P. E., Sperry, J. L., Stubbs, J. R., & Winckler, C. J. (2021). THOR-AABB working party recommendations for a prehospital blood product transfusion program. Prehospital Emergency Care, 26(6), 1–13. https://doi.org/10.1080/10903127.2021.1995089
Yliharju, H., Jama, T., & Nordquist, H. (2022). Initial experiences of prehospital blood product transfusions between 2016 and 2020 in Päijät-Häme hospital district, Finland. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 30, 39. https://doi.org/10.1186/s13049-022-01027-z
Zielinski, M. D., Smoot, D. L., Stubbs, J. R., Jenkins, D. H., Park, M. S., & Zietlow, S. P. (2013). The development and feasibility of a remote damage control resuscitation prehospital plasma transfusion protocol for warfarin reversal for patients with traumatic brain injury. Transfusion, 53 (Suppl.1), 59S–64S. https://doi.org/10.1111/trf.1203
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