Contributions of the ABCDEF bundle to the care of critically ill patients in the ICU: scoping review
DOI:
https://doi.org/10.29352/mill0230.45668Keywords:
nursing; ABCDEF bundle; intensive care unit; critically ill patient; critical careAbstract
Introduction: Hospitalization in intensive care units is associated with complications that compromise patient recovery. Evidence-based strategies, such as the ABCDEF bundle, are essential for improving the quality and safety of care.
Objective: To map the evidence on the contributions of the ABCDEF bundle to the care of critically ill patients in intensive care units.
Methods: A scoping review was conducted according to the guidelines of the Joanna Briggs Institute. The bibliographic search was performed on the EBSCO platform, using MeSH descriptors, in the MEDLINE, CINAHL Complete, Academic Search Complete, MedicLatina, Nursing & Allied Health Collection – Comprehensive, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Cochrane Clinical Answers and Library, Information Science & Technology Abstracts, PubMed, and the Portuguese Open Access Scientific Repository. Studies published in Portuguese or English were included. The selection was documented in a PRISMA diagram, and the data were summarized descriptively.
Results: Forty studies were included. The evidence shows that the ABCDEF bundle reduces the duration of mechanical ventilation, the incidence of delirium, and excessive sedation, thereby decreasing readmission and mortality rates. It promotes early mobilization, strengthens multidisciplinary communication, and optimizes resource management. Family involvement promotes therapeutic adherence, emotional well-being, and satisfaction with care.
Conclusion: The ABCDEF bundle improves the quality of care in intensive care units, demonstrating clinical, organizational, and relational benefits.
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Balas, M. C., Devlin, J. W., Verceles, A. C., Morris, P., & Ely, E. W. (2016). Adapting the ABCDEF bundle to meet the needs of patients requiring prolonged mechanical ventilation in the long-term acute care hospital setting: Historical perspectives and practical implications. Seminars in Respiratory and Critical Care Medicine, 37(1), 119–135. https://doi.org/10.1055/s-0035-1570361
Balas, M., Buckingham, R., Braley, T., Saldi, S., & Vasilevskis, E. (2013). Extending the ABCDE bundle to the post-intensive care unit setting. Journal of Gerontological Nursing, 39(8), 39–51. https://doi.org/10.3928/00989134-20130530-06
Balas, M., Burke, W., Gannon, D., Cohen, M., Colburn, L., Bevil, C., Franz, D., Olsen, K., Ely, E., & Vasilevskis, E. (2013). Implementing the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility bundle into everyday care: Opportunities, challenges, and lessons learned. Critical Care Medicine, 41(9 Suppl 1), S116–S127. https://doi.org/10.1097/CCM.0b013e3182a65bf3
Balas, M., Pun, B., Pasero, C., Engel, H. J., Perme, C., Esbrook, C. L., Kelly, T., Hargett, K., Posa, P., Barr, J., Devlin, J., Morse, A., Barnes-Daly, M., Puntillo, K., Aldrich, J., Schweickert, W., Harmon, L., Byrum, D., Carson, S., … Stollings, J. (2019). Common challenges to effective ABCDEF bundle implementation: The ICU Liberation Campaign experience. Critical Care Nurse, 39(1), 46–60. https://doi.org/10.4037/ccn2019927
Balas, M., Vasilevskis, E., Burke, W., Boehm, L., Pun, B., Olsen, K., Peitz, G., & Ely, E. (2012). Critical care nurses' role in implementing the "ABCDE bundle" into practice. Critical Care Nurse, 32(2), 35–38, 40–47. https://doi.org/10.4037/ccn2012229
Balas, M., Vasilevskis, E., Olsen, K., Schmid, K., Shostrom, V., Cohen, M., Peitz, G., Gannon, D., Sisson, J., Sullivan, J., Stothert, J., Lazure, J., Nuss, S., Jawa, R., Freihaut, F., Ely, E., & Burke, W. (2014). Effectiveness and safety of the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility bundle. Critical Care Medicine, 42(5), 1024–1036. https://doi.org/10.1097/CCM.0000000000000129
Baptista, G., Magalhães, B., Rodrigues, V., & Galvão, A. (2024). Estratégias de comunicação do enfermeiro com o doente crítico em unidades de cuidados intensivos: scoping review. Millenium - Journal of Education, Technologies, and Health, 2(15e), e35355. https://doi.org/10.29352/mill0215e.35355
Bardwell, J., Brimmer, S., & Davis, W. (2020). Implementing the ABCDE bundle, Critical-Care Pain Observation Tool, and Richmond Agitation-Sedation Scale to reduce ventilation time. AACN Advanced Critical Care, 31(1), 16–21. https://doi.org/10.4037/aacnacc2020451
Barnes-Daly, M. A., Pun, B. T., Harmon, L. A., Byrum, D. G., Kumar, V. K., Devlin, J. W., Stollings, J., Puntillo, K., Engel, H., Posa, P., Barr, J., Schweickert, W., Esbrook, C., Hargett, K., Carson, S., Aldrich, J., Ely, E., & Balas, M. (2018). Improving health care for critically ill patients using an evidence-based collaborative approach to ABCDEF bundle dissemination and implementation. Worldviews on Evidence-Based Nursing, 15(3), 206–216. https://doi.org/10.1111/wvn.12290
Barr, J., Fraser, G. L., Puntillo, K., Ely, E. W., Gélinas, C., Dasta, J. F., Davidson, J., Devlin, J., Kress, J., Joffe, A., Coursin, D., Herr, D., Tung, A., Robinson, B., Fontaine, D., Ramsay, M., Riker, R., Sessler, C., Pun, B., … Jaeschke, R. (2013). Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Critical Care Medicine, 41(1), 263–306. https://doi.org/10.1097/CCM.0b013e3182783b72
Boehm, L., Dietrich, M. S., Vasilevskis, E. E., Wells, N., Pandharipande, P., Ely, E. W., & Mion, L. C. (2017). Perceptions of workload burden and adherence to ABCDE bundle among intensive care providers. American Journal of Critical Care, 26(4), e38–e47. https://doi.org/10.4037/ajcc2017544
Boehm, L., Pun, B., Stollings, J., Girard, T., Rock, P., Hough, C., Hsieh, S., Khan, B., Owens, R., Schmidt, G., Smith, S., & Ely, E. (2020). A multisite study of nurse-reported perceptions and practice of ABCDEF bundle components. Intensive and Critical Care Nursing, 60, 1–16. https://doi.org/10.1016/j.iccn.2020.102872
Boehm, L., Vasilevskis, E., Dietrich, M., Wells, N., Ely, E., & Pandharipande, P., & Mion, L. (2017). Organizational domains and variation in attitudes of intensive care providers toward the ABCDE bundle. American Journal of Critical Care, 26(3), e18–e28. https://doi.org/10.4037/ajcc2017297
Boltey, E. M., Iwashyna, T. J., Hyzy, R. C., Watson, S. R., Ross, C., & Costa, D. K. (2019). Ability to predict team members’ behaviors in ICU teams is associated with routine ABCDE implementation. Journal of Critical Care, 51, 192–197. https://doi.org/10.1016/j.jcrc.2019.02.028
Bounds, M., Kram, S., Speroni, K. G., Brice, K., Luschinski, M. A., Harte, S., & Daniel, M. (2016). Effect of ABCDE bundle implementation on prevalence of delirium in intensive care unit patients. American Journal of Critical Care, 25(6), 535–544. https://doi.org/10.4037/ajcc2016209
Chai, E., & Mehl, K. (2015). Implementation of the ABCDE bundle to improve patient outcomes in a rural hospital. Critical Care Nursing Quarterly, 38(3), 232–240. https://doi.org/10.1097/CNQ.0000000000000066
Chen, J., & Huang, M. (2024). Intensive care unit-acquired weakness: Recent insights. Journal of Intensive Medicine, 4(1), 73–80. https://doi.org/10.1016/j.jointm.2023.07.002
Collinsworth, A., Priest, E., Campbell, C., Vasilevskis, E., & Masica, A. (2016). A review of multifaceted care approaches for the prevention and mitigation of delirium in intensive care units. Journal of Intensive Care Medicine, 31(2), 127–141. https://doi.org/10.1177/0885066614553925
Concepcion, S. C. (2013). ABCDEs of ICU awakening. Critical Care Nursing Quarterly, 36(2), 152–156. https://doi.org/10.1097/CNQ.0b013e318283cd7d
Costa, D. K., Valley, T., Miller, M., Manojlovich, M., Watson, S., McLellan, P., Pope, C., Hyzy, R., & Iwashyna, T. (2018). ICU team composition and its association with ABCDE implementation in a quality collaborative. Journal of Critical Care, 44, 1–6. https://doi.org/10.1016/j.jcrc.2017.09.180
Costa, D. K., White, M. R., Ginier, E., Manojlovich, M., Govindan, S., Iwashyna, T. J., & Sales, A. E. (2017). Identifying barriers to delivering the awakening and breathing coordination, delirium, and early exercise/mobility bundle to minimize adverse outcomes for mechanically ventilated patients: A systematic review. Chest, 152(2), 304–311. https://doi.org/10.1016/j.chest.2017.03.054
Dang, S. L. (2013). ABCDEs of ICU: Early mobility. Critical Care Nursing Quarterly, 36(2), 163–168. https://doi.org/10.1097/CNQ.0b013e318283cf45
Davidson, J. E. (2013). Preventing delirium in the intensive care unit. Critical Care Nurse, 33(2), 18–23. https://doi.org/10.4037/ccn2013928
DeMellow, J. M., Kim, T. Y., Romano, P. S., Drake, C., & Balas, M. C. (2020). Factors associated with ABCDE bundle adherence in critically ill adults requiring mechanical ventilation: An observational design. Intensive and Critical Care Nursing, 60, 102873. https://doi.org/10.1016/j.iccn.2020.102873
Demoro, G., Damico, V., Murano, L., Bolgeo, T., D'Alessandro, A., & Dal Molin, A. (2020). Long-term consequences in survivors of critical illness: Analysis of incidence and risk factors. Annali dell'Istituto Superiore di Sanità, 56(1), 59–65. https://doi.org/10.4415/ANN_20_01_09
Desai, S. V., Law, T. J., & Needham, D. M. (2011). Long-term complications of critical care. Critical Care Medicine, 39(2), 371–379. https://doi.org/10.1097/CCM.0b013e3181fd66e5
Ely, E. W. (2017). The ABCDEF bundle: Science and philosophy of how ICU liberation serves patients and families. Critical Care Medicine, 45(2), 321–330. https://doi.org/10.1097/CCM.0000000000002175
Frade-Mera, M. J., Arias-Rivera, S., Zaragoza-García, I., Martí, J. D., Gallart, E., San José-Arribas, A., Velasco-Sanz, T., Blazquez-Martínez, E., & Raurell-Torredà, M. (2022). The impact of ABCDE bundle implementation on patient outcomes: A nationwide cohort study. Nursing in Critical Care, 27(6), 772–783. https://doi.org/10.1111/nicc.12740
Guest, M., Craven, K., Tellson, A. M., Porter, M., James, N., Turley, L., & Smitherman, J. (2024). Reigniting intensive care unit liberation. Critical Care Nurse, 44(4), 19–26. https://doi.org/10.4037/ccn2024629
Hsieh, S., Otusanya, O., Gershengorn, H., Hope, A., Dayton, C., Levi, D., Garcia, M., Prince, D., Mills, M., Fein, D., Colman, S., & Gong, M. (2019). Staged implementation of awakening and breathing, coordination, delirium monitoring and management, and early mobilization bundle improves patient outcomes and reduces hospital costs. Critical Care Medicine, 47(7), 885–893. https://doi.org/10.1097/CCM.0000000000003765
Lee, Y., Kim, K., Lim, C., & Kim, J. S. (2020). Effects of the ABCDE bundle on the prevention of post-intensive care syndrome: A retrospective study. Journal of Advanced Nursing, 76(2), 588–599. https://doi.org/10.1111/jan.14267
Maraboto, E. (2013). ABCDEs of ICU: Choice of sedative. Critical Care Nursing Quarterly, 36(2), 157–162. https://doi.org/10.1097/CNQ.0b013e318283cf10
Marra, A., Ely, E. W., Pandharipande, P., & Patel, M. (2017). The ABCDEF bundle in critical care. Critical Care Clinics, 33(2), 225–243. https://doi.org/10.1016/j.ccc.2016.12.005
Miller, M. A., Govindan, S., Watson, S. R., Hyzy, R. C., & Iwashyna, T. J. (2015). ABCDE, but in that order? A cross-sectional survey of Michigan intensive care unit sedation, delirium, and early mobility practices. Annals of the American Thoracic Society, 12(7), 1066–1071. https://doi.org/10.1513/AnnalsATS.201501-066OC
Morandi, A., Brummel, N. E., & Ely, E. W. (2011). Sedation, delirium and mechanical ventilation: The ‘ABCDE’ approach. Current Opinion in Critical Care, 17(1), 43–49. https://doi.org/10.1097/MCC.0b013e3283427243
Morandi, A., Piva, S., Ely, E. W., Myatra, S. N., Salluh, J. I. F., Amare, D., Azoulay, E., Bellelli, G., Csomos, A., Fan, E., Fagoni, N., Girard, T., La Calle, G., Inoue, S., Lim, C-M., Kaps, R., Kotfis, K., Koh, Y., Misango, D., … Latronico, N. (2017). Worldwide survey of the “Assessing Pain, Both Spontaneous Awakening and Breathing Trials, Choice of Drugs, Delirium Monitoring/Management, Early Exercise/Mobility, and Family Empowerment” (ABCDEF) bundle. Critical Care Medicine, 45(11), e1111–e1122. https://doi.org/10.1097/CCM.0000000000002640
Negro, A., Bambi, S., De Vecchi, M., Isotti, P., Villa, G., Miconi, L., Dossi, M., Ponzetta, G., Rinaldi, L., Radaelli, C., Caballo, C., Leggieri, C., Colombo, S., Cabrini, L., Manara, D., & Zangrillo, A. (2022). The ABCDE bundle implementation in an intensivecare unit: Facilitators and barriers perceived by nurses and doctors. International Journal of Nursing Practice, 28(2), e12984. https://doi.org/10.1111/ijn.12984
Ordem dos Enfermeiros. (2008). Dor: Guia orientador de boa prática. Ordem dos Enfermeiros. Retrieved May 5, 2025. https://shre.ink/7rFO
Pereira, J., Barradas, F., Sequeira, R., Marques, M., Batista, M., Galhardas, M., & Santos, M. (2016). Delirium in critically ill patients: Risk factors modifiable by nurses. Revista de Enfermagem Referência, 4(9), 29–36. http://dx.doi.org/10.12707/RIV16006
Peters, M., Godfrey, C., McInerney, P., Munn, Z., Trico, A., & Khalil, H. (2021). Capítulo 11: Revisões de escopo. In E. Aromataris & Z. Munn (Eds.), Manual JBI para síntese de evidências. JBI. https://syntesemanual.jbi.globa
Pun, B. T., Balas, M. C., Barnes-Daly, M. A., Thompson, J. L., Aldrich, J. M., Barr, J., Byrum, D., Carson, S., Devlin, J., Engel, H., Esbrook, C., Hargett, K., Harmon, L., Hielsberg, C., Jackson, J., Kelly, T., Kumar, V., Millner, L., Morse, A., … Ely, E. (2019). Caring for critically ill patients with the ABCDEF bundle: Results of the ICU Liberation Collaborative in over 15,000 adults. Critical Care Medicine, 47(1), 3–14. https://doi.org/10.1097/CCM.0000000000003482
Ren, X. L., Li, J. H., Peng, C., Chen, H., Wang, H. X., Wei, X. L., & Cheng, Q. H. (2017). Effects of ABCDE bundle on hemodynamics in patients on mechanical ventilation. Medical Science Monitor, 23, 4650–4656. https://doi.org/10.12659/msm.902872
Sá, F. (2023). A família da pessoa em situação crítica – Desocultando o cuidado de enfermagem (1ª ed.). Sabooks/Lusodidacta.
Sociedade Portuguesa de Cuidados Intensivos, & Ordem dos Médicos. (2024). Recomendações para o seguimento da Síndrome Pós-Internamento em Cuidados Intensivos no doente e família. SPCI. https://shre.ink/7rFA
Society of Critical Care Medicine. (n.d.). Society of Critical Care Medicine: ICU Liberation Bundle (A-F). Illinois: Society of Critical Care Medicine. Retrieved May 5, 2025. https://shre.ink/7rFS
Sosnowski, K., Lin, F., Chaboyer, W., Ranse, K., Heffernan, A., & Mitchell, M. (2023). The effect of the ABCDE/ABCDEF bundle on delirium, functional outcomes, and quality of life in critically ill patients: A systematic review and meta-analysis. International Journal of Nursing Studies, 138, 104410. https://doi.org/10.1016/j.ijnurstu.2022.104410
Sosnowski, K., Mitchell, M. L., White, H., Morrison, L., Sutton, J., Sharratt, J., & Lin, F. (2018). A feasibility study of a randomised controlled trial to examine the impact of the ABCDE bundle on quality of life in ICU survivors. Pilot and Feasibility Studies, 4, 32. https://doi.org/10.1186/s40814-017-0224-x
Sosnowski, K., Mitchell, M., Cooke, M., White, H., Morrison, L., & Lin, F. (2021). Effectiveness of the ABCDEF bundle on delirium, functional outcomes and quality of life in intensive care patients: A study protocol for a randomised controlled trial with embedded process evaluation. BMJ Open, 11(7), e044814. https://doi.org/10.1136/bmjopen-2020-044814
Stollings, J., Devlin, J., Lin, J. C., Pun, B., Byrum, D., & Barr, J. (2020). Best practices for conducting interprofessional team rounds to facilitate performance of the ICU Liberation (ABCDEF) bundle. Critical Care Medicine, 48(4), 562–570. https://doi.org/10.1097/CCM.0000000000004197
Stollings, J., Devlin, J., Pun, B., Puntillo, K., Kelly, T., Hargett, K., Morse, A., Esbrook, C., Engel, H., Perme, C., Barnes-Daly, M., Posa, P., Aldrich, J., Barr, J., Carson, S., Schweickert, W., Byrum, D., Harmon, L., Ely, E., & Balas, M. (2019). Implementing the ABCDEF bundle: Top 8 questions asked during the ICU Liberation ABCDEF bundle improvement collaborative. Critical Care, 23(1), 36–45. https://doi.org/10.4037/ccn2019981
Vasilevskis, E., Ely, E., Speroff, T., Pun, B., Boehm, L., & Dittus, R. (2010). The iatrogenic risks: ICU-acquired delirium and weakness-crossing the quality chasm. Chest, 138(5), 1224–1233. https://doi.org/10.1378/chest.10-0466
Zhang, L., Lin, H., Wu, B., Yang, Q., Guo, Y., & Feng, D. (2025). Prevalence and risk factors of post-intensive care syndrome: A systematic review and meta-analysis. PLoS One, 20(1), e0323311. https://doi.org/10.1371/journal.pone.0323311
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